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- NCIT_C63661 IAO_0000115 "A nutritional supplement that is synthesized from adenosine triphosphate (ATP) and the amino acid methionine by the endogenous essential enzyme methionine adenosyltransferase (MAT), with potential antineoplastic activity. Upon administration, S-adenosylmethionine acts as a methyl donor for various transmethylation reactions. In cancer cells, this agent induces the methylation of tumor promoting genes, reverses DNA hypomethylation, and leads to the suppression of oncogene transcription. This induces apoptosis in and inhibits proliferation of susceptible tumor cells." @default.
- NCIT_C63661 NCIT_A32 NCIT_C1909 @default.
- NCIT_C63661 NCIT_NHC0 "C63661" @default.
- NCIT_C63661 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C63661 NCIT_P108 "S-Adenosylmethionine" @default.
- NCIT_C63661 NCIT_P207 "C0036002" @default.
- NCIT_C63661 NCIT_P210 "29908-03-0" @default.
- NCIT_C63661 NCIT_P322 "GDC" @default.
- NCIT_C63661 NCIT_P329 "776686" @default.
- NCIT_C63661 NCIT_P330 "776686" @default.
- NCIT_C63661 NCIT_P350 "C15H22N6O5S" @default.
- NCIT_C63661 NCIT_P366 "S-Adenosylmethionine" @default.
- NCIT_C63661 NCIT_P368 "CHEBI:15414" @default.
- NCIT_C63661 NCIT_P375 "S-Adenosylmethionine" @default.
- NCIT_C63661 NCIT_P399 "776686" @default.
- NCIT_C63661 normalizedInformationContent "100" @default.
- NCIT_C63661 referenceCount "1" @default.
- NCIT_C63661 hasExactSynonym "5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Hydroxide, Inner Salt" @default.
- NCIT_C63661 hasExactSynonym "Active Methionine" @default.
- NCIT_C63661 hasExactSynonym "S-Adenosyl-l-methionine 1,4-Butanedisulfonate" @default.
- NCIT_C63661 hasExactSynonym "S-Adenosyl-l-methionine" @default.
- NCIT_C63661 hasExactSynonym "S-Adenosyl-methionine" @default.
- NCIT_C63661 hasExactSynonym "S-Adenosylmethionine" @default.
- NCIT_C63661 inSubset NCIT_C128784 @default.
- NCIT_C63661 inSubset NCIT_C157711 @default.
- NCIT_C63661 inSubset NCIT_C157712 @default.
- NCIT_C63661 inSubset NCIT_C176424 @default.
- NCIT_C63661 inSubset NCIT_C177537 @default.
- NCIT_C63661 type Class @default.
- NCIT_C63661 isDefinedBy ncit.owl @default.
- NCIT_C63661 label "S-Adenosylmethionine" @default.
- NCIT_C63661 subClassOf NCIT_C1908 @default.
- NCIT_C63661 subClassOf NCIT_C1909 @default.
- NCIT_C63661 subClassOf NCIT_C26170 @default.
- NCIT_C63661 subClassOf NCIT_C275 @default.
- NCIT_C63661 subClassOf NCIT_C63661 @default.