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- NCIT_C63958 IAO_0000115 "An imidazoquinolinamine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines, especially interferon-alpha (INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans' cells, leading to an enhanced activation of T-lymphocytes. Due to its immunostimulatory activity, this agent may potentially be useful as a vaccine adjuvant." @default.
- NCIT_C63958 NCIT_A32 NCIT_C1909 @default.
- NCIT_C63958 NCIT_A7 NCIT_C30108 @default.
- NCIT_C63958 NCIT_A7 NCIT_C30109 @default.
- NCIT_C63958 NCIT_NHC0 "C63958" @default.
- NCIT_C63958 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C63958 NCIT_P107 "Resiquimod" @default.
- NCIT_C63958 NCIT_P108 "Resiquimod" @default.
- NCIT_C63958 NCIT_P207 "C0389573" @default.
- NCIT_C63958 NCIT_P210 "144875-48-9" @default.
- NCIT_C63958 NCIT_P319 "V3DMU7PVXF" @default.
- NCIT_C63958 NCIT_P322 "CTRP" @default.
- NCIT_C63958 NCIT_P322 "FDA" @default.
- NCIT_C63958 NCIT_P322 "GDC" @default.
- NCIT_C63958 NCIT_P325 "A substance being studied in the treatment of some types of skin cancer. When put on the skin, resiquimod causes some immune cells to make certain chemicals that may help them kill tumor cells. It is also being studied to find out if adding it to a tumor vaccine improves the antitumor immune response. It is a type of imidazoquinoline and a type of immunomodulator." @default.
- NCIT_C63958 NCIT_P329 "544217" @default.
- NCIT_C63958 NCIT_P330 "544217" @default.
- NCIT_C63958 NCIT_P350 "C17H22N4O2" @default.
- NCIT_C63958 NCIT_P366 "Resiquimod" @default.
- NCIT_C63958 NCIT_P368 "CHEBI:36706" @default.
- NCIT_C63958 NCIT_P375 "Resiquimod" @default.
- NCIT_C63958 NCIT_P399 "544217" @default.
- NCIT_C63958 normalizedInformationContent "100" @default.
- NCIT_C63958 referenceCount "1" @default.
- NCIT_C63958 hasExactSynonym "4-Amino-2-(ethoxymethyl)-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol" @default.
- NCIT_C63958 hasExactSynonym "R848" @default.
- NCIT_C63958 hasExactSynonym "RESIQUIMOD" @default.
- NCIT_C63958 hasExactSynonym "Resiquimod" @default.
- NCIT_C63958 hasExactSynonym "S 28463" @default.
- NCIT_C63958 hasExactSynonym "resiquimod" @default.
- NCIT_C63958 inSubset NCIT_C116977 @default.
- NCIT_C63958 inSubset NCIT_C116978 @default.
- NCIT_C63958 inSubset NCIT_C128784 @default.
- NCIT_C63958 inSubset NCIT_C157711 @default.
- NCIT_C63958 inSubset NCIT_C157712 @default.
- NCIT_C63958 inSubset NCIT_C176424 @default.
- NCIT_C63958 inSubset NCIT_C177537 @default.
- NCIT_C63958 inSubset NCIT_C63923 @default.
- NCIT_C63958 type Class @default.
- NCIT_C63958 isDefinedBy ncit.owl @default.
- NCIT_C63958 label "Resiquimod" @default.
- NCIT_C63958 subClassOf NCIT_C129820 @default.
- NCIT_C63958 subClassOf NCIT_C1908 @default.
- NCIT_C63958 subClassOf NCIT_C1909 @default.
- NCIT_C63958 subClassOf NCIT_C274 @default.
- NCIT_C63958 subClassOf NCIT_C308 @default.
- NCIT_C63958 subClassOf NCIT_C63958 @default.