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- NCIT_C64260 IAO_0000115 "A recombinant form of asparaginase derived from the bacterium Erwinia chrysanthemi, genetically engineered to be produced in Pseudomonas fluorescens, with potential antineoplastic activity. Upon administration, asparaginase Erwinia chrysanthemi hydrolyzes L-asparagine to L-aspartic acid and ammonia. This depletes cancer cells of asparagine, which blocks protein synthesis and tumor cell proliferation. Asparagine is critical to protein synthesis in cancer cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase Erwinia chrysanthemi can be used as an alternative in patients who are hypersensitive to Escherichia (E.) coli-derived asparaginase products." @default.
- NCIT_C64260 NCIT_A32 NCIT_C1909 @default.
- NCIT_C64260 NCIT_A7 NCIT_C29607 @default.
- NCIT_C64260 NCIT_NHC0 "C64260" @default.
- NCIT_C64260 NCIT_P106 "Enzyme" @default.
- NCIT_C64260 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64260 NCIT_P107 "Asparaginase Erwinia chrysanthemi" @default.
- NCIT_C64260 NCIT_P108 "Asparaginase Erwinia chrysanthemi" @default.
- NCIT_C64260 NCIT_P175 "106977" @default.
- NCIT_C64260 NCIT_P207 "C0771210" @default.
- NCIT_C64260 NCIT_P210 "9015-68-3" @default.
- NCIT_C64260 NCIT_P302 "Acute lymphocytic leukemia; Acute non-lymphocytic leukemia" @default.
- NCIT_C64260 NCIT_P319 "D733ET3F9O" @default.
- NCIT_C64260 NCIT_P322 "CTRP" @default.
- NCIT_C64260 NCIT_P322 "FDA" @default.
- NCIT_C64260 NCIT_P322 "GDC" @default.
- NCIT_C64260 NCIT_P329 "601044" @default.
- NCIT_C64260 NCIT_P330 "601044" @default.
- NCIT_C64260 NCIT_P366 "Asparaginase-Erwinia" @default.
- NCIT_C64260 NCIT_P375 "Asparaginase Erwinia chrysanthemi" @default.
- NCIT_C64260 NCIT_P375 "Recombinant Erwinia asparaginase JZP-458" @default.
- NCIT_C64260 NCIT_P399 "601044" @default.
- NCIT_C64260 normalizedInformationContent "100" @default.
- NCIT_C64260 referenceCount "1" @default.
- NCIT_C64260 hasExactSynonym "ASPARAGINASE ERWINIA CHRYSANTHEMI" @default.
- NCIT_C64260 hasExactSynonym "Asparaginase Erwinia Chrysanthemi (Recombinant)-rywn" @default.
- NCIT_C64260 hasExactSynonym "Asparaginase Erwinia chrysanthemi" @default.
- NCIT_C64260 hasExactSynonym "Asparaginase Erwinia chrysanthemi-rywn" @default.
- NCIT_C64260 hasExactSynonym "Crisantaspase Biobetter JZP-458" @default.
- NCIT_C64260 hasExactSynonym "Crisantaspase" @default.
- NCIT_C64260 hasExactSynonym "Crisantaspasum" @default.
- NCIT_C64260 hasExactSynonym "Erwinase" @default.
- NCIT_C64260 hasExactSynonym "Erwinaze" @default.
- NCIT_C64260 hasExactSynonym "JZP 458" @default.
- NCIT_C64260 hasExactSynonym "JZP-458" @default.
- NCIT_C64260 hasExactSynonym "JZP458" @default.
- NCIT_C64260 hasExactSynonym "PF743" @default.
- NCIT_C64260 hasExactSynonym "RC-P JZP-458" @default.
- NCIT_C64260 hasExactSynonym "Recombinant Asparaginase erwinia chrysanthemi JZP-458" @default.
- NCIT_C64260 hasExactSynonym "Recombinant Crisantaspase JZP-458" @default.
- NCIT_C64260 hasExactSynonym "Recombinant Erwinia asparaginase JZP-458" @default.
- NCIT_C64260 hasExactSynonym "Rylaze" @default.
- NCIT_C64260 inSubset NCIT_C116977 @default.
- NCIT_C64260 inSubset NCIT_C116978 @default.
- NCIT_C64260 inSubset NCIT_C128784 @default.
- NCIT_C64260 inSubset NCIT_C157711 @default.
- NCIT_C64260 inSubset NCIT_C157712 @default.
- NCIT_C64260 inSubset NCIT_C176424 @default.
- NCIT_C64260 inSubset NCIT_C177537 @default.
- NCIT_C64260 inSubset NCIT_C63923 @default.
- NCIT_C64260 type Class @default.
- NCIT_C64260 isDefinedBy ncit.owl @default.
- NCIT_C64260 label "Asparaginase Erwinia chrysanthemi" @default.
- NCIT_C64260 subClassOf NCIT_C177280 @default.
- NCIT_C64260 subClassOf NCIT_C177430 @default.
- NCIT_C64260 subClassOf NCIT_C1908 @default.
- NCIT_C64260 subClassOf NCIT_C1909 @default.
- NCIT_C64260 subClassOf NCIT_C274 @default.
- NCIT_C64260 subClassOf NCIT_C29726 @default.
- NCIT_C64260 subClassOf NCIT_C307 @default.
- NCIT_C64260 subClassOf NCIT_C64260 @default.