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- NCIT_C64541 IAO_0000115 "An orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into the active triphosphate form. As an analogue of deoxycytidine triphosphate, CNDAC triphosphate incorporates into DNA strands during replication, resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue. The unmetabolized prodrug may exhibit antineoplastic activity as well." @default.
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- NCIT_C64541 NCIT_NHC0 "C64541" @default.
- NCIT_C64541 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64541 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64541 NCIT_P107 "Sapacitabine" @default.
- NCIT_C64541 NCIT_P108 "Sapacitabine" @default.
- NCIT_C64541 NCIT_P207 "C0764827" @default.
- NCIT_C64541 NCIT_P210 "151823-14-2" @default.
- NCIT_C64541 NCIT_P319 "W335P73C3L" @default.
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- NCIT_C64541 NCIT_P329 "513165" @default.
- NCIT_C64541 NCIT_P330 "513165" @default.
- NCIT_C64541 NCIT_P350 "C26H42N4O5" @default.
- NCIT_C64541 NCIT_P366 "Sapacitabine" @default.
- NCIT_C64541 NCIT_P375 "Sapacitabine" @default.
- NCIT_C64541 NCIT_P399 "513165" @default.
- NCIT_C64541 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C64541 normalizedInformationContent "100" @default.
- NCIT_C64541 referenceCount "1" @default.
- NCIT_C64541 hasExactSynonym "CS-682" @default.
- NCIT_C64541 hasExactSynonym "CYC682" @default.
- NCIT_C64541 hasExactSynonym "N-(1-(2-Cyano-2-deoxy-beta-D-arabinofuranosyl)-2-oxo-1,2-dihydropyrimidin-4-yl)-hexadecanamide" @default.
- NCIT_C64541 hasExactSynonym "SAPACITABINE" @default.
- NCIT_C64541 hasExactSynonym "Sapacitabine" @default.
- NCIT_C64541 inSubset NCIT_C116977 @default.
- NCIT_C64541 inSubset NCIT_C116978 @default.
- NCIT_C64541 inSubset NCIT_C128784 @default.
- NCIT_C64541 inSubset NCIT_C157711 @default.
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- NCIT_C64541 inSubset NCIT_C176424 @default.
- NCIT_C64541 inSubset NCIT_C177537 @default.
- NCIT_C64541 inSubset NCIT_C63923 @default.
- NCIT_C64541 type Class @default.
- NCIT_C64541 isDefinedBy ncit.owl @default.
- NCIT_C64541 label "Sapacitabine" @default.
- NCIT_C64541 subClassOf B3fe2ea140388d986b87d3ba16e36519b @default.
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