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- NCIT_C64543 IAO_0000115 "A water-soluble triazole prodrug with broad-spectrum antifungal activity. Isavuconazole is absorbed easily, given either orally or intravenously, and is hydrolyzed to its active moiety BAL4815 by plasma esterases. BAL4815 inhibits fungal cytochrome P450 lanosterol 14-alpha-demethylase (CYP51) that catalyzes the conversion of lanosterol to ergosterol, an important component of the fungal cell membrane. Enzyme inhibition by this agent leads to a decrease in ergosterol pool and therefore disturbs synthesis of fungal cell membrane, thereby increasing cell membrane permeability and promoting loss of essential intracellular elements. This ultimately causes fungal cell lysis and death." @default.
- NCIT_C64543 NCIT_NHC0 "C64543" @default.
- NCIT_C64543 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64543 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64543 NCIT_P107 "Isavuconazole" @default.
- NCIT_C64543 NCIT_P108 "Isavuconazole" @default.
- NCIT_C64543 NCIT_P207 "C1832021" @default.
- NCIT_C64543 NCIT_P210 "241479-67-4" @default.
- NCIT_C64543 NCIT_P319 "60UTO373KE" @default.
- NCIT_C64543 NCIT_P322 "CTRP" @default.
- NCIT_C64543 NCIT_P322 "FDA" @default.
- NCIT_C64543 NCIT_P329 "529357" @default.
- NCIT_C64543 NCIT_P330 "529357" @default.
- NCIT_C64543 NCIT_P350 "C22H17F2N5OS" @default.
- NCIT_C64543 NCIT_P366 "Isavuconazole" @default.
- NCIT_C64543 NCIT_P399 "529357" @default.
- NCIT_C64543 normalizedInformationContent "100" @default.
- NCIT_C64543 referenceCount "1" @default.
- NCIT_C64543 hasExactSynonym "BAL8557" @default.
- NCIT_C64543 hasExactSynonym "ISAVUCONAZOLE" @default.
- NCIT_C64543 hasExactSynonym "Isavuconazole" @default.
- NCIT_C64543 inSubset NCIT_C116977 @default.
- NCIT_C64543 inSubset NCIT_C116978 @default.
- NCIT_C64543 inSubset NCIT_C176424 @default.
- NCIT_C64543 inSubset NCIT_C63923 @default.
- NCIT_C64543 type Class @default.
- NCIT_C64543 isDefinedBy ncit.owl @default.
- NCIT_C64543 label "Isavuconazole" @default.
- NCIT_C64543 subClassOf NCIT_C1908 @default.
- NCIT_C64543 subClassOf NCIT_C1909 @default.
- NCIT_C64543 subClassOf NCIT_C254 @default.
- NCIT_C64543 subClassOf NCIT_C514 @default.
- NCIT_C64543 subClassOf NCIT_C64543 @default.