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Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C64544> ?p ?o ?g. }

• NCIT_C64544 IAO_0000115 "An orally bioavailable diaminopyrimidine compound and a cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. CDKs are ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and are frequently overexpressed in cancerous cells. R547 selectively binds to and inhibits CDKs, especially CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1. The inhibition of CDKs results in cell cycle arrest, inhibition of tumor cell proliferation, and induction of apoptosis. By inhibiting CDK activity, R547 also reduces phosphorylation of the retinoblastoma (Rb) protein, thereby preventing activation of transcription factor E2F and leading to further suppression of tumor cell proliferation." @default.
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• NCIT_C64544 NCIT_NHC0 "C64544" @default.
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• NCIT_C64544 NCIT_P108 "CDK Inhibitor R547" @default.
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• NCIT_C64544 normalizedInformationContent "100" @default.
• NCIT_C64544 referenceCount "1" @default.
• NCIT_C64544 hasExactSynonym "CDK Inhibitor R547" @default.
• NCIT_C64544 hasExactSynonym "Cyclin Dependent Kinase Inhibitor R547" @default.
• NCIT_C64544 hasExactSynonym "Cyclin-Dependent Kinase Inhibitor R547" @default.
• NCIT_C64544 hasExactSynonym "R 547" @default.
• NCIT_C64544 hasExactSynonym "R-547" @default.
• NCIT_C64544 hasExactSynonym "R547" @default.
• NCIT_C64544 hasExactSynonym "RO 4584820" @default.
• NCIT_C64544 hasExactSynonym "RO-4584820" @default.
• NCIT_C64544 hasExactSynonym "RO4584820" @default.
• NCIT_C64544 inSubset NCIT_C128784 @default.
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• NCIT_C64544 type Class @default.
• NCIT_C64544 isDefinedBy ncit.owl @default.
• NCIT_C64544 label "CDK Inhibitor R547" @default.
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• NCIT_C64544 subClassOf NCIT_C2189 @default.
• NCIT_C64544 subClassOf NCIT_C274 @default.
• NCIT_C64544 subClassOf NCIT_C471 @default.

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