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- NCIT_C64621 IAO_0000115 "A fully human monoclonal agonistic antibody directed against tumor necrosis factor-alpha (TNF-alpha)-related apoptosis-inducing ligand receptor-2 (TRAIL-R2) with potential antitumor activity. Mimicking the natural ligand TRAIL, lexatumumab binds to and activates TRAIL-R2, which may trigger apoptosis in and inhibit the growth of TRAIL-R2-expressing tumor cells. TRAIL-R2, also known as death receptor 5 (DR5), is a member of the TNF receptor family and is expressed on many malignant cell types." @default.
- NCIT_C64621 NCIT_A32 NCIT_C1909 @default.
- NCIT_C64621 NCIT_A7 NCIT_C18178 @default.
- NCIT_C64621 NCIT_NHC0 "C64621" @default.
- NCIT_C64621 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C64621 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C64621 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64621 NCIT_P108 "Lexatumumab" @default.
- NCIT_C64621 NCIT_P207 "C1721684" @default.
- NCIT_C64621 NCIT_P210 "845816-02-6" @default.
- NCIT_C64621 NCIT_P319 "967Q0SJD77" @default.
- NCIT_C64621 NCIT_P322 "FDA" @default.
- NCIT_C64621 NCIT_P322 "GDC" @default.
- NCIT_C64621 NCIT_P325 "A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL-R2 on the surface of some tumor cells, which may kill the tumor cells. HGS-ETR2 is a type of monoclonal antibody." @default.
- NCIT_C64621 NCIT_P329 "528015" @default.
- NCIT_C64621 NCIT_P330 "528015" @default.
- NCIT_C64621 NCIT_P366 "Lexatumumab" @default.
- NCIT_C64621 NCIT_P375 "Lexatumumab" @default.
- NCIT_C64621 NCIT_P399 "528015" @default.
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- NCIT_C64621 normalizedInformationContent "100" @default.
- NCIT_C64621 referenceCount "1" @default.
- NCIT_C64621 hasExactSynonym "Anti-TRAIL Receptor 2 Monoclonal Antibody HGS-ETR2" @default.
- NCIT_C64621 hasExactSynonym "HGS-ETR2" @default.
- NCIT_C64621 hasExactSynonym "HGS1018" @default.
- NCIT_C64621 hasExactSynonym "LEXATUMUMAB" @default.
- NCIT_C64621 hasExactSynonym "Lexatumumab" @default.
- NCIT_C64621 hasExactSynonym "Monoclonal Antibody HGS-ETR2" @default.
- NCIT_C64621 hasExactSynonym "anti-TRAIL R2 mAb HGS-ETR2" @default.
- NCIT_C64621 hasExactSynonym "lexatumumab" @default.
- NCIT_C64621 inSubset NCIT_C128784 @default.
- NCIT_C64621 inSubset NCIT_C157711 @default.
- NCIT_C64621 inSubset NCIT_C157712 @default.
- NCIT_C64621 inSubset NCIT_C176424 @default.
- NCIT_C64621 inSubset NCIT_C177537 @default.
- NCIT_C64621 inSubset NCIT_C63923 @default.
- NCIT_C64621 type Class @default.
- NCIT_C64621 isDefinedBy ncit.owl @default.
- NCIT_C64621 label "Lexatumumab" @default.
- NCIT_C64621 subClassOf B94e696135c10643c658281fdd487faf2 @default.
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- NCIT_C64621 subClassOf NCIT_C1909 @default.
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- NCIT_C64621 subClassOf NCIT_C274 @default.
- NCIT_C64621 subClassOf NCIT_C307 @default.
- NCIT_C64621 subClassOf NCIT_C308 @default.
- NCIT_C64621 subClassOf NCIT_C64621 @default.