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- NCIT_C64625 IAO_0000115 "A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation." @default.
- NCIT_C64625 NCIT_NHC0 "C64625" @default.
- NCIT_C64625 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64625 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64625 NCIT_P107 "Pregabalin" @default.
- NCIT_C64625 NCIT_P108 "Pregabalin" @default.
- NCIT_C64625 NCIT_P175 "759256" @default.
- NCIT_C64625 NCIT_P207 "C0657912" @default.
- NCIT_C64625 NCIT_P210 "148553-50-8" @default.
- NCIT_C64625 NCIT_P319 "55JG375S6M" @default.
- NCIT_C64625 NCIT_P322 "CTRP" @default.
- NCIT_C64625 NCIT_P322 "FDA" @default.
- NCIT_C64625 NCIT_P325 "A drug used to treat nerve pain caused by diabetes or herpes zoster infection and certain types of seizures. It is being studied in the prevention and treatment of nerve pain in the hands and feet of cancer patients given chemotherapy. Pregabalin is a type of anticonvulsant." @default.
- NCIT_C64625 NCIT_P329 "518288" @default.
- NCIT_C64625 NCIT_P330 "518288" @default.
- NCIT_C64625 NCIT_P350 "C8H17NO2" @default.
- NCIT_C64625 NCIT_P366 "Pregabalin" @default.
- NCIT_C64625 NCIT_P368 "CHEBI:64356" @default.
- NCIT_C64625 NCIT_P399 "518288" @default.
- NCIT_C64625 normalizedInformationContent "100" @default.
- NCIT_C64625 referenceCount "1" @default.
- NCIT_C64625 hasExactSynonym "3-(Aminomethyl)-5-methyl-hexanoic Acid" @default.
- NCIT_C64625 hasExactSynonym "3-Isobutyl GABA" @default.
- NCIT_C64625 hasExactSynonym "CI 1008" @default.
- NCIT_C64625 hasExactSynonym "Lyrica" @default.
- NCIT_C64625 hasExactSynonym "PD 144723" @default.
- NCIT_C64625 hasExactSynonym "PREGABALIN" @default.
- NCIT_C64625 hasExactSynonym "Pregabalin" @default.
- NCIT_C64625 hasExactSynonym "pregabalin" @default.
- NCIT_C64625 inSubset NCIT_C116977 @default.
- NCIT_C64625 inSubset NCIT_C116978 @default.
- NCIT_C64625 inSubset NCIT_C176424 @default.
- NCIT_C64625 inSubset NCIT_C63923 @default.
- NCIT_C64625 type Class @default.
- NCIT_C64625 isDefinedBy ncit.owl @default.
- NCIT_C64625 label "Pregabalin" @default.
- NCIT_C64625 subClassOf NCIT_C1908 @default.
- NCIT_C64625 subClassOf NCIT_C1909 @default.
- NCIT_C64625 subClassOf NCIT_C2198 @default.
- NCIT_C64625 subClassOf NCIT_C241 @default.
- NCIT_C64625 subClassOf NCIT_C264 @default.
- NCIT_C64625 subClassOf NCIT_C64625 @default.
- NCIT_C64625 subClassOf NCIT_C78272 @default.