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- NCIT_C64639 IAO_0000115 "An orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types." @default.
- NCIT_C64639 NCIT_A32 NCIT_C1909 @default.
- NCIT_C64639 NCIT_A7 NCIT_C17322 @default.
- NCIT_C64639 NCIT_NHC0 "C64639" @default.
- NCIT_C64639 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64639 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64639 NCIT_P108 "Crenolanib" @default.
- NCIT_C64639 NCIT_P207 "C1831982" @default.
- NCIT_C64639 NCIT_P210 "670220-88-9" @default.
- NCIT_C64639 NCIT_P319 "LQF7I567TQ" @default.
- NCIT_C64639 NCIT_P322 "FDA" @default.
- NCIT_C64639 NCIT_P322 "GDC" @default.
- NCIT_C64639 NCIT_P329 "518325" @default.
- NCIT_C64639 NCIT_P330 "518325" @default.
- NCIT_C64639 NCIT_P350 "C26H29N5O2" @default.
- NCIT_C64639 NCIT_P366 "CP-868_596" @default.
- NCIT_C64639 NCIT_P375 "Crenolanib" @default.
- NCIT_C64639 NCIT_P399 "518325" @default.
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- NCIT_C64639 NCIT_R125 NCIT_C51037 @default.
- NCIT_C64639 NCIT_R146 NCIT_C17021 @default.
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- NCIT_C64639 NCIT_R146 NCIT_C20130 @default.
- NCIT_C64639 NCIT_R146 NCIT_C26548 @default.
- NCIT_C64639 normalizedInformationContent "100" @default.
- NCIT_C64639 referenceCount "1" @default.
- NCIT_C64639 hasExactSynonym "4-Piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1Hbenzimidazol-1-yl]-8-quinolinyl]-" @default.
- NCIT_C64639 hasExactSynonym "CP-868,596" @default.
- NCIT_C64639 hasExactSynonym "CP-868596" @default.
- NCIT_C64639 hasExactSynonym "CRENOLANIB" @default.
- NCIT_C64639 hasExactSynonym "Crenolanib" @default.
- NCIT_C64639 hasExactSynonym "PDGFR Inhibitor CP-868596" @default.
- NCIT_C64639 hasExactSynonym "[1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine" @default.
- NCIT_C64639 inSubset NCIT_C128784 @default.
- NCIT_C64639 inSubset NCIT_C157711 @default.
- NCIT_C64639 inSubset NCIT_C157712 @default.
- NCIT_C64639 inSubset NCIT_C176424 @default.
- NCIT_C64639 inSubset NCIT_C177537 @default.
- NCIT_C64639 inSubset NCIT_C63923 @default.
- NCIT_C64639 type Class @default.
- NCIT_C64639 isDefinedBy ncit.owl @default.
- NCIT_C64639 label "Crenolanib" @default.
- NCIT_C64639 subClassOf B0a150f6cade0121a9413c350d56f6729 @default.
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- NCIT_C64639 subClassOf NCIT_C1404 @default.
- NCIT_C64639 subClassOf NCIT_C1908 @default.
- NCIT_C64639 subClassOf NCIT_C1909 @default.
- NCIT_C64639 subClassOf NCIT_C1967 @default.
- NCIT_C64639 subClassOf NCIT_C471 @default.
- NCIT_C64639 subClassOf NCIT_C64639 @default.