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- NCIT_C64767 IAO_0000115 "A second-generation E2F1 pathway activator with potential antineoplastic activity. ARQ 171 induces the expression of E2F transcription factor 1, thereby activating the E2F1-mediated checkpoint process. E2F1, down-regulated in cancer cells, regulates expression of genes involved in the cell cycle progression from G1 into S phase. The G1/S checkpoint process selectively induces cell cycle arrest in cancer cells with irreparable DNA damages and triggers subsequent apoptosis, while allowing cell division to proceed in cells without or with minor reparable DNA damage. As a result, this agent exerts anti-tumor activity through checkpoint activation independent of p53 mediated tumor suppression." @default.
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- NCIT_C64767 NCIT_NHC0 "C64767" @default.
- NCIT_C64767 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64767 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64767 NCIT_P108 "E2F1 Pathway Activator ARQ 171" @default.
- NCIT_C64767 NCIT_P207 "C1832018" @default.
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- NCIT_C64767 NCIT_P329 "529342" @default.
- NCIT_C64767 NCIT_P330 "529342" @default.
- NCIT_C64767 NCIT_P366 "ARQ_171" @default.
- NCIT_C64767 NCIT_P375 "E2F1 Pathway Activator ARQ 171" @default.
- NCIT_C64767 NCIT_P399 "529342" @default.
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- NCIT_C64767 referenceCount "1" @default.
- NCIT_C64767 hasExactSynonym "ARQ 171" @default.
- NCIT_C64767 hasExactSynonym "E2F1 Pathway Activator ARQ 171" @default.
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- NCIT_C64767 type Class @default.
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- NCIT_C64767 label "E2F1 Pathway Activator ARQ 171" @default.
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