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- NCIT_C64768 IAO_0000115 "An orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers." @default.
- NCIT_C64768 NCIT_A32 NCIT_C1909 @default.
- NCIT_C64768 NCIT_A7 NCIT_C17476 @default.
- NCIT_C64768 NCIT_NHC0 "C64768" @default.
- NCIT_C64768 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64768 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64768 NCIT_P107 "Vemurafenib" @default.
- NCIT_C64768 NCIT_P108 "Vemurafenib" @default.
- NCIT_C64768 NCIT_P207 "C1832009" @default.
- NCIT_C64768 NCIT_P210 "918504-65-1" @default.
- NCIT_C64768 NCIT_P302 "Advanced Melanoma" @default.
- NCIT_C64768 NCIT_P319 "207SMY3FQT" @default.
- NCIT_C64768 NCIT_P322 "CTRP" @default.
- NCIT_C64768 NCIT_P322 "FDA" @default.
- NCIT_C64768 NCIT_P322 "GDC" @default.
- NCIT_C64768 NCIT_P325 "A substance being studied in the treatment of cancer. BRAF (V600E) kinase is a mutated (changed) form of a cell protein called BRAF. It is found in several types of cancer, including melanoma (a type of skin cancer). Inhibiting this kinase may cause cancer cells to die. BRAF (V600E) kinase is a type of serine/threonine kinase inhibitor and a type of targeted therapy agent." @default.
- NCIT_C64768 NCIT_P329 "528954" @default.
- NCIT_C64768 NCIT_P330 "528954" @default.
- NCIT_C64768 NCIT_P350 "C23H18ClF2N3O3S" @default.
- NCIT_C64768 NCIT_P366 "PLX4032" @default.
- NCIT_C64768 NCIT_P368 "CHEBI:63637" @default.
- NCIT_C64768 NCIT_P375 "Vemurafenib" @default.
- NCIT_C64768 NCIT_P399 "528954" @default.
- NCIT_C64768 NCIT_R124 NCIT_C17710 @default.
- NCIT_C64768 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C64768 NCIT_R125 NCIT_C17828 @default.
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- NCIT_C64768 NCIT_R125 NCIT_C51037 @default.
- NCIT_C64768 normalizedInformationContent "86.239998175184226" @default.
- NCIT_C64768 referenceCount "8" @default.
- NCIT_C64768 hasExactSynonym "1-propanesulfonamide, n-(3-((5-(4-chlorophenyl)-1h-pyrrolo(2,3-b)pyridin-3-yl)carbonyl)-2,4-difluorophenyl)-" @default.
- NCIT_C64768 hasExactSynonym "BRAF (V600E) kinase inhibitor RO5185426" @default.
- NCIT_C64768 hasExactSynonym "BRAF(V600E) Kinase Inhibitor RO5185426" @default.
- NCIT_C64768 hasExactSynonym "PLX-4032" @default.
- NCIT_C64768 hasExactSynonym "PLX4032" @default.
- NCIT_C64768 hasExactSynonym "RG 7204" @default.
- NCIT_C64768 hasExactSynonym "RG7204" @default.
- NCIT_C64768 hasExactSynonym "RO 5185426" @default.
- NCIT_C64768 hasExactSynonym "VEMURAFENIB" @default.
- NCIT_C64768 hasExactSynonym "Vemurafenib" @default.
- NCIT_C64768 hasExactSynonym "Zelboraf" @default.
- NCIT_C64768 inSubset NCIT_C116977 @default.
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- NCIT_C64768 inSubset NCIT_C177537 @default.
- NCIT_C64768 inSubset NCIT_C63923 @default.
- NCIT_C64768 type Class @default.
- NCIT_C64768 isDefinedBy ncit.owl @default.
- NCIT_C64768 label "Vemurafenib" @default.
- NCIT_C64768 subClassOf B2a56e8c6a243802694e5439e827e4329 @default.
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- NCIT_C64768 subClassOf NCIT_C61074 @default.
- NCIT_C64768 subClassOf NCIT_C64768 @default.