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- NCIT_C64772 IAO_0000115 "A highly lipophilic preparation of 7-Ethyl-10-hydroxycamptothecin (SN-38) with potential antineoplastic activity. SN2310 is an oil-in-water emulsion of tocopherol covalently linked, via a succinate linker, to SN-38, a synthetic derivative of the cytotoxic alkaloid camptothecin. After succinate linker is hydrolyzed in vivo, the active moiety SN-38 is released and selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks and inducing lethal double-stranded DNA breaks. This inhibits DNA replication and triggers programmed cell death. SN2310 emulsion provides longer circulation time and potentiates drug exposure as compared to the unconjugated SN-38." @default.
- NCIT_C64772 NCIT_A32 NCIT_C1909 @default.
- NCIT_C64772 NCIT_A7 NCIT_C16516 @default.
- NCIT_C64772 NCIT_NHC0 "C64772" @default.
- NCIT_C64772 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64772 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64772 NCIT_P108 "Tenifatecan" @default.
- NCIT_C64772 NCIT_P207 "C1883354" @default.
- NCIT_C64772 NCIT_P210 "850728-18-6" @default.
- NCIT_C64772 NCIT_P319 "7G0Y719Q80" @default.
- NCIT_C64772 NCIT_P322 "FDA" @default.
- NCIT_C64772 NCIT_P322 "GDC" @default.
- NCIT_C64772 NCIT_P329 "518315" @default.
- NCIT_C64772 NCIT_P330 "518315" @default.
- NCIT_C64772 NCIT_P350 "C55H72N2O9" @default.
- NCIT_C64772 NCIT_P366 "Tocopherol_Succinate_7-Ethyl-10-Hydroxycamptothecin" @default.
- NCIT_C64772 NCIT_P375 "Tenifatecan" @default.
- NCIT_C64772 NCIT_P399 "518315" @default.
- NCIT_C64772 NCIT_R124 NCIT_C17710 @default.
- NCIT_C64772 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C64772 NCIT_R125 NCIT_C25830 @default.
- NCIT_C64772 NCIT_R125 NCIT_C28498 @default.
- NCIT_C64772 NCIT_R125 NCIT_C40828 @default.
- NCIT_C64772 NCIT_R125 NCIT_C41543 @default.
- NCIT_C64772 NCIT_R146 NCIT_C16516 @default.
- NCIT_C64772 NCIT_R146 NCIT_C16554 @default.
- NCIT_C64772 NCIT_R146 NCIT_C16759 @default.
- NCIT_C64772 NCIT_R146 NCIT_C17021 @default.
- NCIT_C64772 NCIT_R146 NCIT_C20027 @default.
- NCIT_C64772 NCIT_R146 NCIT_C20646 @default.
- NCIT_C64772 NCIT_R146 NCIT_C26548 @default.
- NCIT_C64772 normalizedInformationContent "100" @default.
- NCIT_C64772 referenceCount "1" @default.
- NCIT_C64772 hasExactSynonym "(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin- 9-yl (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl Butanedioate" @default.
- NCIT_C64772 hasExactSynonym "SN-2310" @default.
- NCIT_C64772 hasExactSynonym "SN2310" @default.
- NCIT_C64772 hasExactSynonym "TENIFATECAN" @default.
- NCIT_C64772 hasExactSynonym "Tenifatecan" @default.
- NCIT_C64772 hasExactSynonym "Tocopherol Succinate 7-Ethyl-10-Hydroxycamptothecin" @default.
- NCIT_C64772 inSubset NCIT_C128784 @default.
- NCIT_C64772 inSubset NCIT_C157711 @default.
- NCIT_C64772 inSubset NCIT_C157712 @default.
- NCIT_C64772 inSubset NCIT_C176424 @default.
- NCIT_C64772 inSubset NCIT_C177537 @default.
- NCIT_C64772 inSubset NCIT_C63923 @default.
- NCIT_C64772 type Class @default.
- NCIT_C64772 isDefinedBy ncit.owl @default.
- NCIT_C64772 label "Tenifatecan" @default.
- NCIT_C64772 subClassOf B0300b8e8658d391068341c80bf4a3568 @default.
- NCIT_C64772 subClassOf B07bd934e4f55def96cc0bd1310eb9e85 @default.
- NCIT_C64772 subClassOf B1e987804dc7f7a8767a3a170d1cd03ee @default.
- NCIT_C64772 subClassOf B33dd73af47517acb15df361c94ba131c @default.
- NCIT_C64772 subClassOf B7db3ee7b69459606587b5b605c9714ea @default.
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- NCIT_C64772 subClassOf NCIT_C129824 @default.
- NCIT_C64772 subClassOf NCIT_C129825 @default.
- NCIT_C64772 subClassOf NCIT_C1748 @default.
- NCIT_C64772 subClassOf NCIT_C1904 @default.
- NCIT_C64772 subClassOf NCIT_C1908 @default.
- NCIT_C64772 subClassOf NCIT_C1909 @default.
- NCIT_C64772 subClassOf NCIT_C2189 @default.
- NCIT_C64772 subClassOf NCIT_C274 @default.
- NCIT_C64772 subClassOf NCIT_C2843 @default.
- NCIT_C64772 subClassOf NCIT_C471 @default.
- NCIT_C64772 subClassOf NCIT_C64772 @default.