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- NCIT_C64773 IAO_0000115 "Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from a patient and pulsed with a retroviral vector that encodes the T-cell receptor gene specific for a mutated form of p53. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow. Many tumor cell types overexpress mutant p53 proteins, which are associated with the loss of apoptosis regulation and abnormal cell proliferation." @default.
- NCIT_C64773 NCIT_NHC0 "C64773" @default.
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- NCIT_C64773 NCIT_P108 "Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes" @default.
- NCIT_C64773 NCIT_P207 "C1831990" @default.
- NCIT_C64773 NCIT_P329 "523273" @default.
- NCIT_C64773 NCIT_P330 "523273" @default.
- NCIT_C64773 NCIT_P366 "Anti-p53_T_Cell_Receptor-Transduced_Peripheral_Blood_Lymphocytes" @default.
- NCIT_C64773 NCIT_P399 "523273" @default.
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- NCIT_C64773 hasExactSynonym "Anti-p53 T-Cell Receptor Retroviral Vector-Transduced Peripheral Blood Lymphocytes" @default.
- NCIT_C64773 hasExactSynonym "Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes" @default.
- NCIT_C64773 hasExactSynonym "Anti-p53 TCR Retroviral Vector-Transduced PBL" @default.
- NCIT_C64773 hasExactSynonym "Anti-p53 TCR-Transduced PBL" @default.
- NCIT_C64773 inSubset NCIT_C128784 @default.
- NCIT_C64773 inSubset NCIT_C176424 @default.
- NCIT_C64773 type Class @default.
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- NCIT_C64773 label "Anti-p53 T-Cell Receptor-Transduced Peripheral Blood Lymphocytes" @default.
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