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- NCIT_C64779 IAO_0000115 "A targeted prodrug consisting of a recombinant modified form of the Aeromonas protoxin, proaerolysin (PA), bearing a prostate-specific protease cleavage site, with potential antineoplastic activity. When injected directly into the prostate, topsalysin is hydrolyzed to the active toxin aerolysin by the serine protease prostate specific antigen (PSA), a protein overexpressed by prostate cancers and prostate cells in hyperplastic prostatic tissue. Aerolysin molecules then oligomerize to form ring-like heptamers that are incorporated into the lipid bilayers of cell membranes, forming large membrane channels and resulting in the leakage of cellular contents and lysis of PSA-expressing prostate cells." @default.
- NCIT_C64779 NCIT_A32 NCIT_C1909 @default.
- NCIT_C64779 NCIT_NHC0 "C64779" @default.
- NCIT_C64779 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64779 NCIT_P108 "Topsalysin" @default.
- NCIT_C64779 NCIT_P207 "C1831975" @default.
- NCIT_C64779 NCIT_P210 "917121-25-6" @default.
- NCIT_C64779 NCIT_P319 "LSA9D0A43Q" @default.
- NCIT_C64779 NCIT_P322 "FDA" @default.
- NCIT_C64779 NCIT_P322 "GDC" @default.
- NCIT_C64779 NCIT_P329 "517173" @default.
- NCIT_C64779 NCIT_P330 "517173" @default.
- NCIT_C64779 NCIT_P366 "PRX302" @default.
- NCIT_C64779 NCIT_P375 "Topsalysin" @default.
- NCIT_C64779 NCIT_P399 "517173" @default.
- NCIT_C64779 NCIT_R125 NCIT_C17828 @default.
- NCIT_C64779 NCIT_R125 NCIT_C20150 @default.
- NCIT_C64779 NCIT_R125 NCIT_C20480 @default.
- NCIT_C64779 NCIT_R125 NCIT_C40715 @default.
- NCIT_C64779 NCIT_R125 NCIT_C41515 @default.
- NCIT_C64779 NCIT_R125 NCIT_C51037 @default.
- NCIT_C64779 normalizedInformationContent "100" @default.
- NCIT_C64779 referenceCount "1" @default.
- NCIT_C64779 hasExactSynonym "PORxin 302" @default.
- NCIT_C64779 hasExactSynonym "PRX 302" @default.
- NCIT_C64779 hasExactSynonym "PSA-PAH1" @default.
- NCIT_C64779 hasExactSynonym "Pore-forming Protein (Synthetic Proaerolysin) Fusion Protein with Prostate-specific Antigen (Human)" @default.
- NCIT_C64779 hasExactSynonym "TOPSALYSIN" @default.
- NCIT_C64779 hasExactSynonym "Topsalysin" @default.
- NCIT_C64779 inSubset NCIT_C128784 @default.
- NCIT_C64779 inSubset NCIT_C157711 @default.
- NCIT_C64779 inSubset NCIT_C157712 @default.
- NCIT_C64779 inSubset NCIT_C176424 @default.
- NCIT_C64779 inSubset NCIT_C177537 @default.
- NCIT_C64779 inSubset NCIT_C63923 @default.
- NCIT_C64779 type Class @default.
- NCIT_C64779 isDefinedBy ncit.owl @default.
- NCIT_C64779 label "Topsalysin" @default.
- NCIT_C64779 subClassOf B18ffe16cf4f07f0ee053211262756076 @default.
- NCIT_C64779 subClassOf Bbe4fd1e7a249ff35da7be867323b3ebe @default.
- NCIT_C64779 subClassOf NCIT_C163758 @default.
- NCIT_C64779 subClassOf NCIT_C1908 @default.
- NCIT_C64779 subClassOf NCIT_C1909 @default.
- NCIT_C64779 subClassOf NCIT_C274 @default.
- NCIT_C64779 subClassOf NCIT_C64779 @default.