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- NCIT_C64782 IAO_0000115 "The hydrochloride salt form of verubulin, a quinazoline derivative with potential dual antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), verubulin appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death." @default.
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- NCIT_C64782 NCIT_NHC0 "C64782" @default.
- NCIT_C64782 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64782 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64782 NCIT_P107 "Verubulin Hydrochloride" @default.
- NCIT_C64782 NCIT_P108 "Verubulin Hydrochloride" @default.
- NCIT_C64782 NCIT_P207 "C1832001" @default.
- NCIT_C64782 NCIT_P210 "917369-31-4" @default.
- NCIT_C64782 NCIT_P319 "33380QZ0QW" @default.
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- NCIT_C64782 NCIT_P330 "526176" @default.
- NCIT_C64782 NCIT_P350 "C17H17N3O.HCl" @default.
- NCIT_C64782 NCIT_P366 "MPC-6827" @default.
- NCIT_C64782 NCIT_P375 "Verubulin Hydrochloride" @default.
- NCIT_C64782 NCIT_P399 "526176" @default.
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- NCIT_C64782 NCIT_R146 NCIT_C26548 @default.
- NCIT_C64782 normalizedInformationContent "100" @default.
- NCIT_C64782 referenceCount "1" @default.
- NCIT_C64782 hasExactSynonym "Azixa" @default.
- NCIT_C64782 hasExactSynonym "MPC-6827" @default.
- NCIT_C64782 hasExactSynonym "Microtubule Inhibitor MPC-6827" @default.
- NCIT_C64782 hasExactSynonym "N-(4-methoxyphenyl)-n,2-dimethylquinazolin-4-amine Hydrochloride" @default.
- NCIT_C64782 hasExactSynonym "VERUBULIN HYDROCHLORIDE" @default.
- NCIT_C64782 hasExactSynonym "Verubulin Hydrochloride" @default.
- NCIT_C64782 inSubset NCIT_C116977 @default.
- NCIT_C64782 inSubset NCIT_C116978 @default.
- NCIT_C64782 inSubset NCIT_C128784 @default.
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- NCIT_C64782 inSubset NCIT_C177537 @default.
- NCIT_C64782 inSubset NCIT_C63923 @default.
- NCIT_C64782 type Class @default.
- NCIT_C64782 isDefinedBy ncit.owl @default.
- NCIT_C64782 label "Verubulin Hydrochloride" @default.
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