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- NCIT_C64785 IAO_0000115 "A cell-based vaccine comprised of prostate cancer cells transduced with an adenoviral vector encoding human RTVP-1 (AdRTVP-1), with potential antineoplastic and immunostimulating activities. RTVP-1, also referred to as glioma pathogenesis-related protein 1 (GLIP1), is down-regulated in prostate tumors. Regulated by tumor suppressor p53, the expression of RTVP-1 functions as a tumor suppressor, and is abundant in normal human prostate epithelial cells as well as in differentiated macrophages. Administration of this vaccine leads to an induction of apoptosis through the expression of RTVP-1 and results in a reduction in cellular proliferation in prostate cancer cells. In addition, this cancer-cell based vaccine may induce a cytotoxic T lymphocyte (CTL) response against prostate specific tumor associated antigens, resulting in an immune-mediated prostate cancer cell death. Furthermore, RTVP-1 stimulates CTL and natural killer (NK) cell activities." @default.
- NCIT_C64785 NCIT_NHC0 "C64785" @default.
- NCIT_C64785 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C64785 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64785 NCIT_P107 "AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine" @default.
- NCIT_C64785 NCIT_P108 "AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine" @default.
- NCIT_C64785 NCIT_P207 "C1832007" @default.
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- NCIT_C64785 NCIT_P329 "526815" @default.
- NCIT_C64785 NCIT_P330 "526815" @default.
- NCIT_C64785 NCIT_P366 "AdRTVP-1-Transduced_Prostate_Cancer_Cell-Based_Vaccine" @default.
- NCIT_C64785 NCIT_P399 "526815" @default.
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- NCIT_C64785 hasExactSynonym "AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine" @default.
- NCIT_C64785 hasExactSynonym "Adenoviral Vector-Mediated RTVP-1 Gene-modified Prostate Cancer Cell-based Vaccine" @default.
- NCIT_C64785 inSubset NCIT_C116977 @default.
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- NCIT_C64785 type Class @default.
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- NCIT_C64785 label "AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine" @default.
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