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- NCIT_C64845 IAO_0000115 "A plasmid DNA encoding the A chain of the diphtheria toxin (DT-A) driven by the transcriptional regulatory sequences of human H19, with potential antineoplastic activity. Because the expression of DT-A is under the control of H19 promotor elements, DT-A is selectively expressed in tumor cells capable of turning on H-19. DT-A catalyzes ADP-ribosylation of translation elongation factor 2 (EF-2), resulting in the inhibition of protein synthesis and apoptosis. In addition, DT-A protein released from lysed cells cannot enter and kill neighboring cells because of the absence of the DT-B chain, further enhancing the selective cytotoxicity of this agent. Human H19 is a paternally-imprinted, oncofetal gene encoding an RNA product; it acts as a riboregulator in gene expression and is found at substantial levels in different human tumor cell types while its expression in normal adult tissue is limited." @default.
- NCIT_C64845 NCIT_A7 NCIT_C17546 @default.
- NCIT_C64845 NCIT_NHC0 "C64845" @default.
- NCIT_C64845 NCIT_P106 "Gene or Genome" @default.
- NCIT_C64845 NCIT_P106 "Organic Chemical" @default.
- NCIT_C64845 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C64845 NCIT_P107 "DTA-H19 Plasmid" @default.
- NCIT_C64845 NCIT_P108 "DTA-H19 Plasmid" @default.
- NCIT_C64845 NCIT_P207 "C1831996" @default.
- NCIT_C64845 NCIT_P322 "CTRP" @default.
- NCIT_C64845 NCIT_P329 "525721" @default.
- NCIT_C64845 NCIT_P330 "525721" @default.
- NCIT_C64845 NCIT_P366 "DTA-H19_Plasmid" @default.
- NCIT_C64845 NCIT_P399 "525721" @default.
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- NCIT_C64845 normalizedInformationContent "100" @default.
- NCIT_C64845 referenceCount "1" @default.
- NCIT_C64845 hasExactSynonym "DTA-H19 Plasmid" @default.
- NCIT_C64845 hasExactSynonym "DTA-H19" @default.
- NCIT_C64845 hasExactSynonym "Diphtheria Toxin A-H19 Plasmid" @default.
- NCIT_C64845 inSubset NCIT_C116977 @default.
- NCIT_C64845 inSubset NCIT_C116978 @default.
- NCIT_C64845 inSubset NCIT_C128784 @default.
- NCIT_C64845 inSubset NCIT_C176424 @default.
- NCIT_C64845 type Class @default.
- NCIT_C64845 isDefinedBy ncit.owl @default.
- NCIT_C64845 label "DTA-H19 Plasmid" @default.
- NCIT_C64845 subClassOf B17a43767ea536ce9d4e6bd89d1dc17bd @default.
- NCIT_C64845 subClassOf B17eb35aa741184f6b68dcd42ade0f42c @default.
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- NCIT_C64845 subClassOf Bcd0be53e17e8e6e58d45c6a02cad429a @default.
- NCIT_C64845 subClassOf Bfc912c6830a66f3fdc122e5e65dd8415 @default.
- NCIT_C64845 subClassOf NCIT_C129821 @default.
- NCIT_C64845 subClassOf NCIT_C1908 @default.
- NCIT_C64845 subClassOf NCIT_C1909 @default.
- NCIT_C64845 subClassOf NCIT_C274 @default.
- NCIT_C64845 subClassOf NCIT_C307 @default.
- NCIT_C64845 subClassOf NCIT_C64845 @default.