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- NCIT_C649 IAO_0000115 "The hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2 (D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting." @default.
- NCIT_C649 NCIT_A6 NCIT_C62046 @default.
- NCIT_C649 NCIT_NHC0 "C649" @default.
- NCIT_C649 NCIT_P106 "Organic Chemical" @default.
- NCIT_C649 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C649 NCIT_P108 "Metoclopramide Hydrochloride" @default.
- NCIT_C649 NCIT_P175 "354467" @default.
- NCIT_C649 NCIT_P207 "C0887128" @default.
- NCIT_C649 NCIT_P210 "7232-21-5" @default.
- NCIT_C649 NCIT_P319 "W1792A2RVD" @default.
- NCIT_C649 NCIT_P322 "FDA" @default.
- NCIT_C649 NCIT_P325 "A drug that increases the motility (movements and contractions) of the stomach and upper intestine. It is used to treat certain stomach problems and nausea and vomiting caused by chemotherapy. It is a type of antiemetic and a type of motility agent." @default.
- NCIT_C649 NCIT_P329 "39502" @default.
- NCIT_C649 NCIT_P330 "39502" @default.
- NCIT_C649 NCIT_P350 "C14H22ClN3O2.HCl.H2O" @default.
- NCIT_C649 NCIT_P366 "Metoclopramide" @default.
- NCIT_C649 NCIT_P368 "CHEBI:6899" @default.
- NCIT_C649 NCIT_P399 "39502" @default.
- NCIT_C649 NCIT_R122 NCIT_C16484 @default.
- NCIT_C649 NCIT_R122 NCIT_C16486 @default.
- NCIT_C649 NCIT_R122 NCIT_C16554 @default.
- NCIT_C649 NCIT_R122 NCIT_C16865 @default.
- NCIT_C649 NCIT_R122 NCIT_C16946 @default.
- NCIT_C649 NCIT_R122 NCIT_C17021 @default.
- NCIT_C649 NCIT_R122 NCIT_C17287 @default.
- NCIT_C649 NCIT_R122 NCIT_C20027 @default.
- NCIT_C649 NCIT_R122 NCIT_C26548 @default.
- NCIT_C649 NCIT_R122 NCIT_C28459 @default.
- NCIT_C649 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C649 referenceCount "3" @default.
- NCIT_C649 hasExactSynonym "METOCLOPRAMIDE HYDROCHLORIDE" @default.
- NCIT_C649 hasExactSynonym "Metoclopramide Hydrochloride" @default.
- NCIT_C649 hasExactSynonym "Reglan" @default.
- NCIT_C649 inSubset NCIT_C176424 @default.
- NCIT_C649 inSubset NCIT_C63923 @default.
- NCIT_C649 type Class @default.
- NCIT_C649 isDefinedBy ncit.owl @default.
- NCIT_C649 label "Metoclopramide Hydrochloride" @default.
- NCIT_C649 subClassOf Bb8f92b3dbe19afd969dc576e247bab66 @default.
- NCIT_C649 subClassOf Bc3133bf35d6e452962580d98b97b59a8 @default.
- NCIT_C649 subClassOf NCIT_C1908 @default.
- NCIT_C649 subClassOf NCIT_C1909 @default.
- NCIT_C649 subClassOf NCIT_C267 @default.
- NCIT_C649 subClassOf NCIT_C649 @default.
- NCIT_C649 subClassOf NCIT_C78272 @default.