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- NCIT_C65110 IAO_0000115 "The liposomal preparation of oxaliplatin, an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group'. A leaving group is an atom or a group of atoms that is displaced as a stable species taking with it its bonding electrons. After displacement of the labile oxalate ligand leaving group, the active oxaliplatin derivatives (monoaquo and diaquo DACH platinum) alkylate macromolecules, and form both inter- and intra-strand platinum-DNA crosslinks, thereby inhibiting DNA replication and resulting in cytotoxicity. The DACH side chain appears to inhibit DNA repair mechanism, therefore overcoming the limits observed in other platinum-based therapies." @default.
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- NCIT_C65110 NCIT_NHC0 "C65110" @default.
- NCIT_C65110 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65110 NCIT_P108 "Liposomal Oxaliplatin" @default.
- NCIT_C65110 NCIT_P207 "C1831940" @default.
- NCIT_C65110 NCIT_P329 "500373" @default.
- NCIT_C65110 NCIT_P330 "500373" @default.
- NCIT_C65110 NCIT_P366 "Liposomal_Oxaliplatin" @default.
- NCIT_C65110 NCIT_P399 "500373" @default.
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- NCIT_C65110 referenceCount "1" @default.
- NCIT_C65110 hasExactSynonym "Liposomal Oxaliplatin" @default.
- NCIT_C65110 hasExactSynonym "Lipoxal" @default.
- NCIT_C65110 inSubset NCIT_C176424 @default.
- NCIT_C65110 type Class @default.
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- NCIT_C65110 label "Liposomal Oxaliplatin" @default.
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