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- NCIT_C65213 IAO_0000115 "The hydrochloride salt form of acolbifene, a fourth-generation estrogen receptor modulator (SERM) with potential lipid lowering and antineoplastic activity. Acolbifene specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. Acolbifene acts as an estrogen antagonist in uterine and breast tissue, thereby blocking the effects of estrogen in these tissues. This may inhibit tumor cell proliferation in ER-positive tumor cells. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In bone, it decreases bone resorption and bone turnover and increases bone mineral density." @default.
- NCIT_C65213 NCIT_A32 NCIT_C1909 @default.
- NCIT_C65213 NCIT_A6 NCIT_C64183 @default.
- NCIT_C65213 NCIT_A7 NCIT_C38361 @default.
- NCIT_C65213 NCIT_NHC0 "C65213" @default.
- NCIT_C65213 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65213 NCIT_P107 "Acolbifene Hydrochloride" @default.
- NCIT_C65213 NCIT_P108 "Acolbifene Hydrochloride" @default.
- NCIT_C65213 NCIT_P207 "C1879543" @default.
- NCIT_C65213 NCIT_P210 "252555-01-4" @default.
- NCIT_C65213 NCIT_P319 "KXC7811DBY" @default.
- NCIT_C65213 NCIT_P322 "CTRP" @default.
- NCIT_C65213 NCIT_P322 "FDA" @default.
- NCIT_C65213 NCIT_P322 "GDC" @default.
- NCIT_C65213 NCIT_P325 "A substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM)." @default.
- NCIT_C65213 NCIT_P329 "636416" @default.
- NCIT_C65213 NCIT_P330 "636416" @default.
- NCIT_C65213 NCIT_P350 "C29H31NO4.ClH" @default.
- NCIT_C65213 NCIT_P366 "Acolbifene_Hydrochloride" @default.
- NCIT_C65213 NCIT_P375 "Acolbifene Hydrochloride" @default.
- NCIT_C65213 NCIT_P399 "636416" @default.
- NCIT_C65213 normalizedInformationContent "100" @default.
- NCIT_C65213 referenceCount "1" @default.
- NCIT_C65213 hasExactSynonym "ACOLBIFENE HYDROCHLORIDE" @default.
- NCIT_C65213 hasExactSynonym "Acolbifene Hydrochloride" @default.
- NCIT_C65213 hasExactSynonym "acolbifene hydrochloride" @default.
- NCIT_C65213 inSubset NCIT_C116977 @default.
- NCIT_C65213 inSubset NCIT_C116978 @default.
- NCIT_C65213 inSubset NCIT_C128784 @default.
- NCIT_C65213 inSubset NCIT_C157711 @default.
- NCIT_C65213 inSubset NCIT_C157712 @default.
- NCIT_C65213 inSubset NCIT_C176424 @default.
- NCIT_C65213 inSubset NCIT_C177537 @default.
- NCIT_C65213 inSubset NCIT_C63923 @default.
- NCIT_C65213 type Class @default.
- NCIT_C65213 isDefinedBy ncit.owl @default.
- NCIT_C65213 label "Acolbifene Hydrochloride" @default.
- NCIT_C65213 subClassOf NCIT_C129818 @default.
- NCIT_C65213 subClassOf NCIT_C147908 @default.
- NCIT_C65213 subClassOf NCIT_C163758 @default.
- NCIT_C65213 subClassOf NCIT_C1821 @default.
- NCIT_C65213 subClassOf NCIT_C1892 @default.
- NCIT_C65213 subClassOf NCIT_C1908 @default.
- NCIT_C65213 subClassOf NCIT_C1909 @default.
- NCIT_C65213 subClassOf NCIT_C274 @default.
- NCIT_C65213 subClassOf NCIT_C481 @default.
- NCIT_C65213 subClassOf NCIT_C483 @default.
- NCIT_C65213 subClassOf NCIT_C547 @default.
- NCIT_C65213 subClassOf NCIT_C548 @default.
- NCIT_C65213 subClassOf NCIT_C65213 @default.