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- NCIT_C65220 IAO_0000115 "A recombinant dimeric fusion protein consisting of the extracellular CD2-binding domain of the human leukocyte function-associated antigen 3 (LFA-3; CD58) linked to the Fc portion of human immunoglobulin G1 (IgG1) with potential immunosuppressive activity. Alefacept binds to the CD2 receptor expressed on the majority of T lymphocytes, blocking the binding of endogenous LFA-3, located on antigen-presenting cells (APCs), to the CD2 receptor; the activation and proliferation of T lymphocytes in response to LFA-3 binding is thus inhibited. In addition, binding of the IgG1 moiety of this agent to the Fc gamma receptor on the surface of natural killer (NK)cells may bridge NK cells and target T lymphocytes, initiating NK cell-mediated apoptosis of T lymphocytes." @default.
- NCIT_C65220 NCIT_A32 NCIT_C1909 @default.
- NCIT_C65220 NCIT_A7 NCIT_C15174 @default.
- NCIT_C65220 NCIT_NHC0 "C65220" @default.
- NCIT_C65220 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65220 NCIT_P107 "Alefacept" @default.
- NCIT_C65220 NCIT_P108 "Alefacept" @default.
- NCIT_C65220 NCIT_P207 "C0962603" @default.
- NCIT_C65220 NCIT_P210 "222535-22-0" @default.
- NCIT_C65220 NCIT_P319 "ELK3V90G6C" @default.
- NCIT_C65220 NCIT_P322 "CTRP" @default.
- NCIT_C65220 NCIT_P322 "FDA" @default.
- NCIT_C65220 NCIT_P322 "GDC" @default.
- NCIT_C65220 NCIT_P325 "A drug that is used to treat certain skin conditions and is being studied in the treatment of cutaneous (skin-related) T-cell cancer and T-cell non-Hodgkin lymphoma. Alefacept is made by combining part of an antibody with a protein that blocks the growth some types of T cells. It is a type of fusion protein and a type of immunosuppressant." @default.
- NCIT_C65220 NCIT_P329 "531798" @default.
- NCIT_C65220 NCIT_P330 "531798" @default.
- NCIT_C65220 NCIT_P366 "Alefacept" @default.
- NCIT_C65220 NCIT_P375 "Alefacept" @default.
- NCIT_C65220 NCIT_P399 "531798" @default.
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- NCIT_C65220 NCIT_R72 NCIT_C104083 @default.
- NCIT_C65220 NCIT_R72 NCIT_C12219 @default.
- NCIT_C65220 NCIT_R72 NCIT_C12476 @default.
- NCIT_C65220 NCIT_R72 NCIT_C12508 @default.
- NCIT_C65220 NCIT_R72 NCIT_C12535 @default.
- NCIT_C65220 NCIT_R72 NCIT_C12542 @default.
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- NCIT_C65220 NCIT_R72 NCIT_C21599 @default.
- NCIT_C65220 NCIT_R72 NCIT_C32725 @default.
- NCIT_C65220 NCIT_R72 NCIT_C33061 @default.
- NCIT_C65220 NCIT_R72 NCIT_C38434 @default.
- NCIT_C65220 NCIT_R72 NCIT_C38439 @default.
- NCIT_C65220 NCIT_R72 NCIT_C39567 @default.
- NCIT_C65220 NCIT_R72 NCIT_C39568 @default.
- NCIT_C65220 normalizedInformationContent "100" @default.
- NCIT_C65220 referenceCount "1" @default.
- NCIT_C65220 hasExactSynonym "ALEFACEPT" @default.
- NCIT_C65220 hasExactSynonym "Alefacept" @default.
- NCIT_C65220 hasExactSynonym "Amevive" @default.
- NCIT_C65220 hasExactSynonym "LFA3TIP" @default.
- NCIT_C65220 hasExactSynonym "alefacept" @default.
- NCIT_C65220 inSubset NCIT_C116977 @default.
- NCIT_C65220 inSubset NCIT_C116978 @default.
- NCIT_C65220 inSubset NCIT_C128784 @default.
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- NCIT_C65220 inSubset NCIT_C177537 @default.
- NCIT_C65220 inSubset NCIT_C63923 @default.
- NCIT_C65220 type Class @default.
- NCIT_C65220 isDefinedBy ncit.owl @default.
- NCIT_C65220 label "Alefacept" @default.
- NCIT_C65220 subClassOf B30d59e0ba5781c8b5e90e2b36ce5fe41 @default.
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- NCIT_C65220 subClassOf NCIT_C574 @default.
- NCIT_C65220 subClassOf NCIT_C65220 @default.