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- NCIT_C65229 IAO_0000115 "A semisynthetic, broad spectrum beta-lactam penicillin with antibacterial activity. Amdinocillin specifically binds to and inactivates penicillin-binding protein 2 (PBP 2) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Given the fact that most beta-lactam penicillins bind almost exclusively to PBPs 1 and 3, amdinocillin is able to synergize with other penicillins in the treatment against bacterial infections." @default.
- NCIT_C65229 NCIT_A5 NCIT_C76216 @default.
- NCIT_C65229 NCIT_NHC0 "C65229" @default.
- NCIT_C65229 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65229 NCIT_P108 "Amdinocillin" @default.
- NCIT_C65229 NCIT_P207 "C0002435" @default.
- NCIT_C65229 NCIT_P210 "32887-01-7" @default.
- NCIT_C65229 NCIT_P319 "V10579P3QZ" @default.
- NCIT_C65229 NCIT_P322 "FDA" @default.
- NCIT_C65229 NCIT_P350 "C15H23N3O3S" @default.
- NCIT_C65229 NCIT_P366 "Amdinocillin" @default.
- NCIT_C65229 NCIT_P368 "CHEBI:51208" @default.
- NCIT_C65229 normalizedInformationContent "100" @default.
- NCIT_C65229 referenceCount "1" @default.
- NCIT_C65229 hasExactSynonym "AMDINOCILLIN" @default.
- NCIT_C65229 hasExactSynonym "Amdinocillin" @default.
- NCIT_C65229 inSubset NCIT_C63923 @default.
- NCIT_C65229 type Class @default.
- NCIT_C65229 isDefinedBy ncit.owl @default.
- NCIT_C65229 label "Amdinocillin" @default.
- NCIT_C65229 subClassOf NCIT_C1500 @default.
- NCIT_C65229 subClassOf NCIT_C1908 @default.
- NCIT_C65229 subClassOf NCIT_C1909 @default.
- NCIT_C65229 subClassOf NCIT_C254 @default.
- NCIT_C65229 subClassOf NCIT_C258 @default.
- NCIT_C65229 subClassOf NCIT_C260 @default.
- NCIT_C65229 subClassOf NCIT_C65229 @default.