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- NCIT_C65267 IAO_0000115 "A diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function." @default.
- NCIT_C65267 NCIT_A5 NCIT_C65268 @default.
- NCIT_C65267 NCIT_NHC0 "C65267" @default.
- NCIT_C65267 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65267 NCIT_P108 "Bitolterol" @default.
- NCIT_C65267 NCIT_P207 "C0053817" @default.
- NCIT_C65267 NCIT_P210 "30392-40-6" @default.
- NCIT_C65267 NCIT_P319 "9KY0QXD6LI" @default.
- NCIT_C65267 NCIT_P322 "FDA" @default.
- NCIT_C65267 NCIT_P350 "C28H31NO5" @default.
- NCIT_C65267 NCIT_P366 "Bitolterol" @default.
- NCIT_C65267 NCIT_P368 "CHEBI:3133" @default.
- NCIT_C65267 normalizedInformationContent "100" @default.
- NCIT_C65267 referenceCount "1" @default.
- NCIT_C65267 hasExactSynonym "BITOLTEROL" @default.
- NCIT_C65267 hasExactSynonym "Bitolterol" @default.
- NCIT_C65267 inSubset NCIT_C63923 @default.
- NCIT_C65267 type Class @default.
- NCIT_C65267 isDefinedBy ncit.owl @default.
- NCIT_C65267 label "Bitolterol" @default.
- NCIT_C65267 subClassOf NCIT_C1908 @default.
- NCIT_C65267 subClassOf NCIT_C1909 @default.
- NCIT_C65267 subClassOf NCIT_C29712 @default.
- NCIT_C65267 subClassOf NCIT_C29747 @default.
- NCIT_C65267 subClassOf NCIT_C319 @default.
- NCIT_C65267 subClassOf NCIT_C48149 @default.
- NCIT_C65267 subClassOf NCIT_C65267 @default.
- NCIT_C65267 subClassOf NCIT_C78272 @default.
- NCIT_C65267 subClassOf NCIT_C78273 @default.
- NCIT_C65267 subClassOf NCIT_C87053 @default.