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- NCIT_C65272 IAO_0000115 "The sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP)." @default.
- NCIT_C65272 NCIT_A6 NCIT_C65271 @default.
- NCIT_C65272 NCIT_NHC0 "C65272" @default.
- NCIT_C65272 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65272 NCIT_P108 "Bromfenac Sodium" @default.
- NCIT_C65272 NCIT_P207 "C0107211" @default.
- NCIT_C65272 NCIT_P210 "120638-55-3" @default.
- NCIT_C65272 NCIT_P319 "8ECV571Y37" @default.
- NCIT_C65272 NCIT_P322 "FDA" @default.
- NCIT_C65272 NCIT_P350 "2C15H11BrNO3.2Na.3H2O" @default.
- NCIT_C65272 NCIT_P366 "Bromfenac_Sodium" @default.
- NCIT_C65272 NCIT_P368 "CHEBI:59176" @default.
- NCIT_C65272 normalizedInformationContent "100" @default.
- NCIT_C65272 referenceCount "1" @default.
- NCIT_C65272 hasExactSynonym "BROMFENAC SODIUM" @default.
- NCIT_C65272 hasExactSynonym "Bromfenac Sodium" @default.
- NCIT_C65272 inSubset NCIT_C63923 @default.
- NCIT_C65272 type Class @default.
- NCIT_C65272 isDefinedBy ncit.owl @default.
- NCIT_C65272 label "Bromfenac Sodium" @default.
- NCIT_C65272 subClassOf NCIT_C1908 @default.
- NCIT_C65272 subClassOf NCIT_C1909 @default.
- NCIT_C65272 subClassOf NCIT_C2198 @default.
- NCIT_C65272 subClassOf NCIT_C2356 @default.
- NCIT_C65272 subClassOf NCIT_C241 @default.
- NCIT_C65272 subClassOf NCIT_C257 @default.
- NCIT_C65272 subClassOf NCIT_C65272 @default.
- NCIT_C65272 subClassOf NCIT_C78272 @default.