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- NCIT_C65278 IAO_0000115 "An orally available synthetic form of the calcitriol prohormone calcifediol (25-hydroxyvitamin D), which can be used for vitamin D supplementation, and with potential immunomodulating activity. Upon oral administration, calcifediol is taken up by the body and converted, in the kidneys, to the active form calcitriol (1,25-dihydroxyvitamin D or 1,25(OH)2D). This form increases and normalizes vitamin D plasma levels, which, in turn, regulates calcium plasma levels, and normalizes elevated parathyroid hormone (PTH) levels by suppressing both PTH synthesis, and secretion. Vitamin D modulates and enhances the innate and adaptive immune responses. This may improve unregulated inflammation and prevents the production of pro-inflammatory cytokines. Specifically, vitamin D binds to its receptor vitamin D receptor (VDR) which is widely expressed on immune cells and epithelial cells. This stimulates neutrophils, macrophages, and natural killer (NK) cells, and activates epithelial cells to produce antimicrobial peptides (AMPs). In addition, upon infection, vitamin D promotes the migration of myeloid dendritic cells (mDCs) to lymphoid organs where they activate B- and T-lymphocytes." @default.
- NCIT_C65278 NCIT_NHC0 "C65278" @default.
- NCIT_C65278 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65278 NCIT_P108 "Calcifediol" @default.
- NCIT_C65278 NCIT_P207 "C0006657" @default.
- NCIT_C65278 NCIT_P210 "63283-36-3" @default.
- NCIT_C65278 NCIT_P319 "P6YZ13C99Q" @default.
- NCIT_C65278 NCIT_P322 "FDA" @default.
- NCIT_C65278 NCIT_P350 "C27H44O2.H2O" @default.
- NCIT_C65278 NCIT_P366 "Calcifediol" @default.
- NCIT_C65278 normalizedInformationContent "100" @default.
- NCIT_C65278 referenceCount "1" @default.
- NCIT_C65278 hasExactSynonym "CALCIFEDIOL" @default.
- NCIT_C65278 hasExactSynonym "Calcifediol" @default.
- NCIT_C65278 inSubset NCIT_C173381 @default.
- NCIT_C65278 inSubset NCIT_C173383 @default.
- NCIT_C65278 inSubset NCIT_C63923 @default.
- NCIT_C65278 type Class @default.
- NCIT_C65278 isDefinedBy ncit.owl @default.
- NCIT_C65278 label "Calcifediol" @default.
- NCIT_C65278 subClassOf NCIT_C1505 @default.
- NCIT_C65278 subClassOf NCIT_C1908 @default.
- NCIT_C65278 subClassOf NCIT_C39713 @default.
- NCIT_C65278 subClassOf NCIT_C65278 @default.