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- NCIT_C65284 IAO_0000115 "A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. Candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure." @default.
- NCIT_C65284 NCIT_NHC0 "C65284" @default.
- NCIT_C65284 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65284 NCIT_P108 "Candesartan" @default.
- NCIT_C65284 NCIT_P207 "C0717550" @default.
- NCIT_C65284 NCIT_P210 "139481-59-7" @default.
- NCIT_C65284 NCIT_P319 "S8Q36MD2XX" @default.
- NCIT_C65284 NCIT_P322 "FDA" @default.
- NCIT_C65284 NCIT_P350 "C24H20N6O3" @default.
- NCIT_C65284 NCIT_P366 "Candesartan" @default.
- NCIT_C65284 NCIT_P368 "CHEBI:3347" @default.
- NCIT_C65284 normalizedInformationContent "100" @default.
- NCIT_C65284 referenceCount "1" @default.
- NCIT_C65284 hasExactSynonym "2-Ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-benzoimidazole-4-carboxylic Acid" @default.
- NCIT_C65284 hasExactSynonym "CANDESARTAN" @default.
- NCIT_C65284 hasExactSynonym "Candesartan" @default.
- NCIT_C65284 inSubset NCIT_C173381 @default.
- NCIT_C65284 inSubset NCIT_C173383 @default.
- NCIT_C65284 inSubset NCIT_C63923 @default.
- NCIT_C65284 type Class @default.
- NCIT_C65284 isDefinedBy ncit.owl @default.
- NCIT_C65284 label "Candesartan" @default.
- NCIT_C65284 subClassOf NCIT_C1908 @default.
- NCIT_C65284 subClassOf NCIT_C1909 @default.
- NCIT_C65284 subClassOf NCIT_C270 @default.
- NCIT_C65284 subClassOf NCIT_C65284 @default.
- NCIT_C65284 subClassOf NCIT_C66930 @default.
- NCIT_C65284 subClassOf NCIT_C78274 @default.