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- NCIT_C65327 IAO_0000115 "The olamine salt form of ciclopirox, a synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX)." @default.
- NCIT_C65327 NCIT_A6 NCIT_C61677 @default.
- NCIT_C65327 NCIT_NHC0 "C65327" @default.
- NCIT_C65327 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65327 NCIT_P108 "Ciclopirox Olamine" @default.
- NCIT_C65327 NCIT_P207 "C0126169" @default.
- NCIT_C65327 NCIT_P210 "41621-49-2" @default.
- NCIT_C65327 NCIT_P319 "50MD4SB4AP" @default.
- NCIT_C65327 NCIT_P322 "FDA" @default.
- NCIT_C65327 NCIT_P350 "C12H17NO2.C2H7NO" @default.
- NCIT_C65327 NCIT_P366 "Ciclopirox_Olamine" @default.
- NCIT_C65327 NCIT_P368 "CHEBI:31398" @default.
- NCIT_C65327 normalizedInformationContent "100" @default.
- NCIT_C65327 referenceCount "1" @default.
- NCIT_C65327 hasExactSynonym "CICLOPIROX OLAMINE" @default.
- NCIT_C65327 hasExactSynonym "Ciclopirox Olamine" @default.
- NCIT_C65327 inSubset NCIT_C63923 @default.
- NCIT_C65327 type Class @default.
- NCIT_C65327 isDefinedBy ncit.owl @default.
- NCIT_C65327 label "Ciclopirox Olamine" @default.
- NCIT_C65327 subClassOf NCIT_C1908 @default.
- NCIT_C65327 subClassOf NCIT_C1909 @default.
- NCIT_C65327 subClassOf NCIT_C254 @default.
- NCIT_C65327 subClassOf NCIT_C514 @default.
- NCIT_C65327 subClassOf NCIT_C65327 @default.