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- NCIT_C65337 IAO_0000115 "An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors." @default.
- NCIT_C65337 NCIT_A32 NCIT_C1909 @default.
- NCIT_C65337 NCIT_NHC0 "C65337" @default.
- NCIT_C65337 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65337 NCIT_P108 "Clioquinol" @default.
- NCIT_C65337 NCIT_P175 "3531" @default.
- NCIT_C65337 NCIT_P207 "C0021978" @default.
- NCIT_C65337 NCIT_P210 "130-26-7" @default.
- NCIT_C65337 NCIT_P319 "7BHQ856EJ5" @default.
- NCIT_C65337 NCIT_P322 "FDA" @default.
- NCIT_C65337 NCIT_P322 "GDC" @default.
- NCIT_C65337 NCIT_P329 "653982" @default.
- NCIT_C65337 NCIT_P330 "653982" @default.
- NCIT_C65337 NCIT_P350 "C9H5ClINO" @default.
- NCIT_C65337 NCIT_P366 "Clioquinol" @default.
- NCIT_C65337 NCIT_P375 "Clioquinol" @default.
- NCIT_C65337 NCIT_P399 "653982" @default.
- NCIT_C65337 NCIT_R125 NCIT_C17710 @default.
- NCIT_C65337 NCIT_R125 NCIT_C17828 @default.
- NCIT_C65337 NCIT_R125 NCIT_C20480 @default.
- NCIT_C65337 NCIT_R125 NCIT_C21079 @default.
- NCIT_C65337 NCIT_R125 NCIT_C28498 @default.
- NCIT_C65337 NCIT_R125 NCIT_C40515 @default.
- NCIT_C65337 normalizedInformationContent "100" @default.
- NCIT_C65337 referenceCount "1" @default.
- NCIT_C65337 hasExactSynonym "5-Chloro-7-iodo-8-hydroxyquinoline" @default.
- NCIT_C65337 hasExactSynonym "5-Chloro-7-iodo-quinolin-8-ol" @default.
- NCIT_C65337 hasExactSynonym "AI3-16451" @default.
- NCIT_C65337 hasExactSynonym "CLIOQUINOL" @default.
- NCIT_C65337 hasExactSynonym "Clioquinol" @default.
- NCIT_C65337 hasExactSynonym "Iodochlorohydroxyquinoline" @default.
- NCIT_C65337 hasExactSynonym "Mycoquin" @default.
- NCIT_C65337 inSubset NCIT_C128784 @default.
- NCIT_C65337 inSubset NCIT_C157711 @default.
- NCIT_C65337 inSubset NCIT_C157712 @default.
- NCIT_C65337 inSubset NCIT_C176424 @default.
- NCIT_C65337 inSubset NCIT_C177537 @default.
- NCIT_C65337 inSubset NCIT_C63923 @default.
- NCIT_C65337 type Class @default.
- NCIT_C65337 isDefinedBy ncit.owl @default.
- NCIT_C65337 label "Clioquinol" @default.
- NCIT_C65337 subClassOf B9a30d88bb72413598b91635f44fbbd11 @default.
- NCIT_C65337 subClassOf Bc35dc0384e0570eda96e384774c3c945 @default.
- NCIT_C65337 subClassOf NCIT_C1742 @default.
- NCIT_C65337 subClassOf NCIT_C1908 @default.
- NCIT_C65337 subClassOf NCIT_C1909 @default.
- NCIT_C65337 subClassOf NCIT_C254 @default.
- NCIT_C65337 subClassOf NCIT_C274 @default.
- NCIT_C65337 subClassOf NCIT_C65337 @default.