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- NCIT_C65364 IAO_0000115 "A human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication." @default.
- NCIT_C65364 NCIT_NHC0 "C65364" @default.
- NCIT_C65364 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65364 NCIT_P108 "Darunavir" @default.
- NCIT_C65364 NCIT_P207 "C1435444" @default.
- NCIT_C65364 NCIT_P210 "206361-99-1" @default.
- NCIT_C65364 NCIT_P319 "YO603Y8113" @default.
- NCIT_C65364 NCIT_P322 "FDA" @default.
- NCIT_C65364 NCIT_P350 "C27H37N3O7S" @default.
- NCIT_C65364 NCIT_P366 "Darunavir" @default.
- NCIT_C65364 NCIT_P368 "CHEBI:367163" @default.
- NCIT_C65364 normalizedInformationContent "100" @default.
- NCIT_C65364 referenceCount "1" @default.
- NCIT_C65364 hasExactSynonym "(3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate" @default.
- NCIT_C65364 hasExactSynonym "DARUNAVIR" @default.
- NCIT_C65364 hasExactSynonym "Darunavir" @default.
- NCIT_C65364 hasExactSynonym "TMC114" @default.
- NCIT_C65364 inSubset NCIT_C173381 @default.
- NCIT_C65364 inSubset NCIT_C173383 @default.
- NCIT_C65364 inSubset NCIT_C63923 @default.
- NCIT_C65364 type Class @default.
- NCIT_C65364 isDefinedBy ncit.owl @default.
- NCIT_C65364 label "Darunavir" @default.
- NCIT_C65364 subClassOf NCIT_C1660 @default.
- NCIT_C65364 subClassOf NCIT_C1908 @default.
- NCIT_C65364 subClassOf NCIT_C1909 @default.
- NCIT_C65364 subClassOf NCIT_C254 @default.
- NCIT_C65364 subClassOf NCIT_C281 @default.
- NCIT_C65364 subClassOf NCIT_C471 @default.
- NCIT_C65364 subClassOf NCIT_C65364 @default.
- NCIT_C65364 subClassOf NCIT_C783 @default.
- NCIT_C65364 subClassOf NCIT_C97366 @default.