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- NCIT_C65470 IAO_0000115 "A broad-spectrum, carbapenem antibiotic with bactericidal and beta-lactamase resistant activities. Doripenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, particularly PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and eventually lysis of the bacterial cell wall. This agent is two- to 16-fold more potent than imipenem and comparable to ertapenem and meropenem." @default.
- NCIT_C65470 NCIT_NHC0 "C65470" @default.
- NCIT_C65470 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65470 NCIT_P108 "Doripenem" @default.
- NCIT_C65470 NCIT_P207 "C0389169" @default.
- NCIT_C65470 NCIT_P210 "148016-81-3" @default.
- NCIT_C65470 NCIT_P302 "Intraabdominal Infection, Urinary Tract Infection" @default.
- NCIT_C65470 NCIT_P319 "BHV525JOBH" @default.
- NCIT_C65470 NCIT_P322 "FDA" @default.
- NCIT_C65470 NCIT_P350 "C15H24N4O6S2" @default.
- NCIT_C65470 NCIT_P366 "Doripenem" @default.
- NCIT_C65470 normalizedInformationContent "100" @default.
- NCIT_C65470 referenceCount "1" @default.
- NCIT_C65470 hasExactSynonym "DORIPENEM" @default.
- NCIT_C65470 hasExactSynonym "Doribax" @default.
- NCIT_C65470 hasExactSynonym "Doripenem" @default.
- NCIT_C65470 hasExactSynonym "FInibax" @default.
- NCIT_C65470 hasExactSynonym "S-4661" @default.
- NCIT_C65470 inSubset NCIT_C63923 @default.
- NCIT_C65470 type Class @default.
- NCIT_C65470 isDefinedBy ncit.owl @default.
- NCIT_C65470 label "Doripenem" @default.
- NCIT_C65470 subClassOf NCIT_C1908 @default.
- NCIT_C65470 subClassOf NCIT_C1909 @default.
- NCIT_C65470 subClassOf NCIT_C254 @default.
- NCIT_C65470 subClassOf NCIT_C258 @default.
- NCIT_C65470 subClassOf NCIT_C260 @default.
- NCIT_C65470 subClassOf NCIT_C65470 @default.