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- NCIT_C65475 IAO_0000115 "A dibenzoxepin derivative and tricyclic antidepressant (TCA) with antipruritic, antidepressive and anxiolytic activities. Doxepin blocks the reuptake of norepinephrine and serotonin (5-HT) into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their neurotransmission. Doxepin also has antagonistic effects on histamine H1, 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is mediated through inhibition of histamine receptors." @default.
- NCIT_C65475 NCIT_A5 NCIT_C29006 @default.
- NCIT_C65475 NCIT_NHC0 "C65475" @default.
- NCIT_C65475 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65475 NCIT_P108 "Doxepin" @default.
- NCIT_C65475 NCIT_P207 "C0013085" @default.
- NCIT_C65475 NCIT_P210 "1668-19-5" @default.
- NCIT_C65475 NCIT_P302 "Insomnia" @default.
- NCIT_C65475 NCIT_P319 "5ASJ6HUZ7D" @default.
- NCIT_C65475 NCIT_P322 "FDA" @default.
- NCIT_C65475 NCIT_P366 "Doxepin" @default.
- NCIT_C65475 NCIT_P368 "CHEBI:4710" @default.
- NCIT_C65475 normalizedInformationContent "100" @default.
- NCIT_C65475 referenceCount "1" @default.
- NCIT_C65475 hasExactSynonym "DOXEPIN" @default.
- NCIT_C65475 hasExactSynonym "Doxepin" @default.
- NCIT_C65475 hasExactSynonym "Silenor" @default.
- NCIT_C65475 inSubset NCIT_C63923 @default.
- NCIT_C65475 type Class @default.
- NCIT_C65475 isDefinedBy ncit.owl @default.
- NCIT_C65475 label "Doxepin" @default.
- NCIT_C65475 subClassOf NCIT_C1908 @default.
- NCIT_C65475 subClassOf NCIT_C1909 @default.
- NCIT_C65475 subClassOf NCIT_C265 @default.
- NCIT_C65475 subClassOf NCIT_C65475 @default.
- NCIT_C65475 subClassOf NCIT_C78272 @default.
- NCIT_C65475 subClassOf NCIT_C94727 @default.