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- NCIT_C65495 NCIT_A5 NCIT_C65496 @default.
- NCIT_C65495 NCIT_NHC0 "C65495" @default.
- NCIT_C65495 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65495 NCIT_P108 "Duloxetine" @default.
- NCIT_C65495 NCIT_P207 "C0245561" @default.
- NCIT_C65495 NCIT_P210 "116539-59-4" @default.
- NCIT_C65495 NCIT_P302 "Generalized Anxiety Disorder, Diabetic Peripheral Neuropathic Pain, Major Depressive Disorder" @default.
- NCIT_C65495 NCIT_P319 "O5TNM5N07U" @default.
- NCIT_C65495 NCIT_P322 "FDA" @default.
- NCIT_C65495 NCIT_P325 "A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes. It is also being studied in the treatment of peripheral neuropathy caused by certain anticancer drugs. Cymbalta increases the amount of certain chemicals in the brain that help relieve depression and pain. It is a type of serotonin and norepinephrine reuptake inhibitor." @default.
- NCIT_C65495 NCIT_P325 "An orally bioavailable fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SNRIs), with central pain inhibitory, anxiolytic and antidepressant activities. Upon oral administration, duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. This potentiates serotonergic and noradrenergic activities in the central nervous system (CNS), and alleviates anxiety, depression, and neuropathy sensations, such as neuropathic pain." @default.
- NCIT_C65495 NCIT_P350 "C18H19NOS" @default.
- NCIT_C65495 NCIT_P366 "Duloxetine" @default.
- NCIT_C65495 NCIT_P368 "CHEBI:36795" @default.
- NCIT_C65495 normalizedInformationContent "100" @default.
- NCIT_C65495 referenceCount "1" @default.
- NCIT_C65495 hasExactSynonym "DULOXETINE" @default.
- NCIT_C65495 hasExactSynonym "Duloxetine" @default.
- NCIT_C65495 hasExactSynonym "duloxetine" @default.
- NCIT_C65495 inSubset NCIT_C63923 @default.
- NCIT_C65495 type Class @default.
- NCIT_C65495 isDefinedBy ncit.owl @default.
- NCIT_C65495 label "Duloxetine" @default.
- NCIT_C65495 subClassOf NCIT_C1908 @default.
- NCIT_C65495 subClassOf NCIT_C1909 @default.
- NCIT_C65495 subClassOf NCIT_C265 @default.
- NCIT_C65495 subClassOf NCIT_C65495 @default.
- NCIT_C65495 subClassOf NCIT_C78272 @default.