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- NCIT_C65503 IAO_0000115 "A organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity." @default.
- NCIT_C65503 NCIT_NHC0 "C65503" @default.
- NCIT_C65503 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65503 NCIT_P108 "Ebselen" @default.
- NCIT_C65503 NCIT_P207 "C0058903" @default.
- NCIT_C65503 NCIT_P210 "60940-34-3" @default.
- NCIT_C65503 NCIT_P319 "40X2P7DPGH" @default.
- NCIT_C65503 NCIT_P322 "FDA" @default.
- NCIT_C65503 NCIT_P350 "C13H9NOSe" @default.
- NCIT_C65503 NCIT_P366 "Ebselen" @default.
- NCIT_C65503 normalizedInformationContent "100" @default.
- NCIT_C65503 referenceCount "1" @default.
- NCIT_C65503 hasExactSynonym "EBSELEN" @default.
- NCIT_C65503 hasExactSynonym "Ebselen" @default.
- NCIT_C65503 inSubset NCIT_C63923 @default.
- NCIT_C65503 type Class @default.
- NCIT_C65503 isDefinedBy ncit.owl @default.
- NCIT_C65503 label "Ebselen" @default.
- NCIT_C65503 subClassOf NCIT_C1323 @default.
- NCIT_C65503 subClassOf NCIT_C1908 @default.
- NCIT_C65503 subClassOf NCIT_C1909 @default.
- NCIT_C65503 subClassOf NCIT_C2198 @default.
- NCIT_C65503 subClassOf NCIT_C2356 @default.
- NCIT_C65503 subClassOf NCIT_C241 @default.
- NCIT_C65503 subClassOf NCIT_C257 @default.
- NCIT_C65503 subClassOf NCIT_C26170 @default.
- NCIT_C65503 subClassOf NCIT_C275 @default.
- NCIT_C65503 subClassOf NCIT_C471 @default.
- NCIT_C65503 subClassOf NCIT_C65503 @default.
- NCIT_C65503 subClassOf NCIT_C78272 @default.