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- NCIT_C65513 IAO_0000115 "A synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription." @default.
- NCIT_C65513 NCIT_NHC0 "C65513" @default.
- NCIT_C65513 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65513 NCIT_P108 "Entecavir" @default.
- NCIT_C65513 NCIT_P207 "C0971023" @default.
- NCIT_C65513 NCIT_P210 "209216-23-9" @default.
- NCIT_C65513 NCIT_P319 "5968Y6H45M" @default.
- NCIT_C65513 NCIT_P322 "FDA" @default.
- NCIT_C65513 NCIT_P329 "617986" @default.
- NCIT_C65513 NCIT_P330 "617986" @default.
- NCIT_C65513 NCIT_P350 "C12H15N5O3.H2O" @default.
- NCIT_C65513 NCIT_P366 "Entecavir" @default.
- NCIT_C65513 NCIT_P368 "CHEBI:59902" @default.
- NCIT_C65513 NCIT_P399 "617986" @default.
- NCIT_C65513 normalizedInformationContent "100" @default.
- NCIT_C65513 referenceCount "1" @default.
- NCIT_C65513 hasExactSynonym "6H-Purin-6-One, 2-Amino-1,9-Dihydro-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)- Monohydrate" @default.
- NCIT_C65513 hasExactSynonym "9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)Guanine Monohydrate" @default.
- NCIT_C65513 hasExactSynonym "BMS-200475-01" @default.
- NCIT_C65513 hasExactSynonym "Baraclude" @default.
- NCIT_C65513 hasExactSynonym "ENTECAVIR" @default.
- NCIT_C65513 hasExactSynonym "ETV" @default.
- NCIT_C65513 hasExactSynonym "Entecavir" @default.
- NCIT_C65513 hasExactSynonym "SQ-34676" @default.
- NCIT_C65513 hasExactSynonym "SQ34676" @default.
- NCIT_C65513 inSubset NCIT_C176424 @default.
- NCIT_C65513 inSubset NCIT_C63923 @default.
- NCIT_C65513 type Class @default.
- NCIT_C65513 isDefinedBy ncit.owl @default.
- NCIT_C65513 label "Entecavir" @default.
- NCIT_C65513 subClassOf NCIT_C1589 @default.
- NCIT_C65513 subClassOf NCIT_C1908 @default.
- NCIT_C65513 subClassOf NCIT_C1909 @default.
- NCIT_C65513 subClassOf NCIT_C254 @default.
- NCIT_C65513 subClassOf NCIT_C281 @default.
- NCIT_C65513 subClassOf NCIT_C471 @default.
- NCIT_C65513 subClassOf NCIT_C65513 @default.
- NCIT_C65513 subClassOf NCIT_C97452 @default.