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- NCIT_C65539 IAO_0000115 "The sodium salt of the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell." @default.
- NCIT_C65539 NCIT_A6 NCIT_C65538 @default.
- NCIT_C65539 NCIT_NHC0 "C65539" @default.
- NCIT_C65539 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65539 NCIT_P108 "Esomeprazole Sodium" @default.
- NCIT_C65539 NCIT_P207 "C1337241" @default.
- NCIT_C65539 NCIT_P210 "161796-78-7" @default.
- NCIT_C65539 NCIT_P319 "L2C9GWQ43H" @default.
- NCIT_C65539 NCIT_P322 "FDA" @default.
- NCIT_C65539 NCIT_P350 "C17H18N3O3S.Na" @default.
- NCIT_C65539 NCIT_P366 "Esomeprazole_Sodium" @default.
- NCIT_C65539 normalizedInformationContent "100" @default.
- NCIT_C65539 referenceCount "1" @default.
- NCIT_C65539 hasExactSynonym "1H-Benzimidazole, 6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2- pyridinyl)methyl]sulfinyl]-, Sodium Salt (1:1)" @default.
- NCIT_C65539 hasExactSynonym "ESOMEPRAZOLE SODIUM" @default.
- NCIT_C65539 hasExactSynonym "Esomeprazole Sodium" @default.
- NCIT_C65539 inSubset NCIT_C63923 @default.
- NCIT_C65539 type Class @default.
- NCIT_C65539 isDefinedBy ncit.owl @default.
- NCIT_C65539 label "Esomeprazole Sodium" @default.
- NCIT_C65539 subClassOf NCIT_C1908 @default.
- NCIT_C65539 subClassOf NCIT_C1909 @default.
- NCIT_C65539 subClassOf NCIT_C29701 @default.
- NCIT_C65539 subClassOf NCIT_C29723 @default.
- NCIT_C65539 subClassOf NCIT_C65539 @default.
- NCIT_C65539 subClassOf NCIT_C78276 @default.