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- NCIT_C65629 IAO_0000115 "An orally available, non-purine inhibitor of xanthine oxidase with uric acid lowering activity. Upon oral administration, febuxostat selectively and noncompetitively inhibits the activity of xanthine oxidase, an enzyme that converts oxypurines, including hypoxanthine and xanthine, into uric acid. By inhibiting xanthine oxidase, uric acid production is reduced and serum uric acid levels are lowered. Febuxostat may provide protection against acute renal failure caused by the excessive release of uric acid that occurs upon massive tumor cell lysis resulting from the treatment of some malignancies." @default.
- NCIT_C65629 NCIT_A32 NCIT_C1909 @default.
- NCIT_C65629 NCIT_NHC0 "C65629" @default.
- NCIT_C65629 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65629 NCIT_P108 "Febuxostat" @default.
- NCIT_C65629 NCIT_P171 "16339094" @default.
- NCIT_C65629 NCIT_P207 "C0249529" @default.
- NCIT_C65629 NCIT_P210 "144060-53-7" @default.
- NCIT_C65629 NCIT_P319 "101V0R1N2E" @default.
- NCIT_C65629 NCIT_P322 "FDA" @default.
- NCIT_C65629 NCIT_P322 "GDC" @default.
- NCIT_C65629 NCIT_P329 "743107" @default.
- NCIT_C65629 NCIT_P330 "743107" @default.
- NCIT_C65629 NCIT_P350 "C16H16N2O3S" @default.
- NCIT_C65629 NCIT_P366 "Febuxostat" @default.
- NCIT_C65629 NCIT_P368 "CHEBI:31596" @default.
- NCIT_C65629 NCIT_P375 "Febuxostat" @default.
- NCIT_C65629 NCIT_P399 "743107" @default.
- NCIT_C65629 normalizedInformationContent "100" @default.
- NCIT_C65629 referenceCount "1" @default.
- NCIT_C65629 hasExactSynonym "2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic Acid" @default.
- NCIT_C65629 hasExactSynonym "Adenuric" @default.
- NCIT_C65629 hasExactSynonym "FEBUXOSTAT" @default.
- NCIT_C65629 hasExactSynonym "Febuxostat" @default.
- NCIT_C65629 hasExactSynonym "TMX 67" @default.
- NCIT_C65629 hasExactSynonym "Uloric" @default.
- NCIT_C65629 inSubset NCIT_C128784 @default.
- NCIT_C65629 inSubset NCIT_C157711 @default.
- NCIT_C65629 inSubset NCIT_C157712 @default.
- NCIT_C65629 inSubset NCIT_C176424 @default.
- NCIT_C65629 inSubset NCIT_C177537 @default.
- NCIT_C65629 inSubset NCIT_C63923 @default.
- NCIT_C65629 type Class @default.
- NCIT_C65629 isDefinedBy ncit.owl @default.
- NCIT_C65629 label "Febuxostat" @default.
- NCIT_C65629 subClassOf NCIT_C1637 @default.
- NCIT_C65629 subClassOf NCIT_C1908 @default.
- NCIT_C65629 subClassOf NCIT_C1909 @default.
- NCIT_C65629 subClassOf NCIT_C26170 @default.
- NCIT_C65629 subClassOf NCIT_C471 @default.
- NCIT_C65629 subClassOf NCIT_C65629 @default.
- NCIT_C65629 subClassOf NCIT_C921 @default.