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- NCIT_C65761 IAO_0000115 "A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow." @default.
- NCIT_C65761 NCIT_A5 NCIT_C47542 @default.
- NCIT_C65761 NCIT_NHC0 "C65761" @default.
- NCIT_C65761 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65761 NCIT_P108 "Fosinopril" @default.
- NCIT_C65761 NCIT_P207 "C0118168" @default.
- NCIT_C65761 NCIT_P210 "98048-97-6" @default.
- NCIT_C65761 NCIT_P319 "R43D2573WO" @default.
- NCIT_C65761 NCIT_P322 "FDA" @default.
- NCIT_C65761 NCIT_P350 "C30H46NO7P" @default.
- NCIT_C65761 NCIT_P366 "Fosinopril" @default.
- NCIT_C65761 NCIT_P368 "CHEBI:5163" @default.
- NCIT_C65761 normalizedInformationContent "100" @default.
- NCIT_C65761 referenceCount "1" @default.
- NCIT_C65761 hasExactSynonym "FOSINOPRIL" @default.
- NCIT_C65761 hasExactSynonym "Fosinopril" @default.
- NCIT_C65761 inSubset NCIT_C63923 @default.
- NCIT_C65761 type Class @default.
- NCIT_C65761 isDefinedBy ncit.owl @default.
- NCIT_C65761 label "Fosinopril" @default.
- NCIT_C65761 subClassOf NCIT_C1908 @default.
- NCIT_C65761 subClassOf NCIT_C1909 @default.
- NCIT_C65761 subClassOf NCIT_C247 @default.
- NCIT_C65761 subClassOf NCIT_C270 @default.
- NCIT_C65761 subClassOf NCIT_C471 @default.
- NCIT_C65761 subClassOf NCIT_C65761 @default.
- NCIT_C65761 subClassOf NCIT_C78274 @default.
- NCIT_C65761 subClassOf NCIT_C783 @default.