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- NCIT_C658 IAO_0000115 "An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)" @default.
- NCIT_C658 NCIT_A32 NCIT_C1909 @default.
- NCIT_C658 NCIT_A7 NCIT_C449 @default.
- NCIT_C658 NCIT_NHC0 "C658" @default.
- NCIT_C658 NCIT_P106 "Antibiotic" @default.
- NCIT_C658 NCIT_P106 "Organic Chemical" @default.
- NCIT_C658 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C658 NCIT_P107 "Plicamycin" @default.
- NCIT_C658 NCIT_P108 "Plicamycin" @default.
- NCIT_C658 NCIT_P175 "24559" @default.
- NCIT_C658 NCIT_P207 "C0026234" @default.
- NCIT_C658 NCIT_P210 "18378-89-7" @default.
- NCIT_C658 NCIT_P319 "NIJ123W41V" @default.
- NCIT_C658 NCIT_P322 "CTRP" @default.
- NCIT_C658 NCIT_P322 "FDA" @default.
- NCIT_C658 NCIT_P322 "GDC" @default.
- NCIT_C658 NCIT_P325 "A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic." @default.
- NCIT_C658 NCIT_P329 "41738" @default.
- NCIT_C658 NCIT_P330 "41738" @default.
- NCIT_C658 NCIT_P350 "C52H76O24" @default.
- NCIT_C658 NCIT_P366 "Plicamycin" @default.
- NCIT_C658 NCIT_P368 "CHEBI:31856" @default.
- NCIT_C658 NCIT_P375 "Plicamycin" @default.
- NCIT_C658 NCIT_P399 "41738" @default.
- NCIT_C658 normalizedInformationContent "100" @default.
- NCIT_C658 referenceCount "1" @default.
- NCIT_C658 hasExactSynonym "A-2371" @default.
- NCIT_C658 hasExactSynonym "Aureolic acid" @default.
- NCIT_C658 hasExactSynonym "MTH" @default.
- NCIT_C658 hasExactSynonym "Mithracin" @default.
- NCIT_C658 hasExactSynonym "Mithracine" @default.
- NCIT_C658 hasExactSynonym "Mithramycin" @default.
- NCIT_C658 hasExactSynonym "PA-144" @default.
- NCIT_C658 hasExactSynonym "PLICAMYCIN" @default.
- NCIT_C658 hasExactSynonym "Plicamycin" @default.
- NCIT_C658 hasExactSynonym "mithramycin" @default.
- NCIT_C658 hasExactSynonym "plicamycin" @default.
- NCIT_C658 inSubset NCIT_C116977 @default.
- NCIT_C658 inSubset NCIT_C116978 @default.
- NCIT_C658 inSubset NCIT_C128784 @default.
- NCIT_C658 inSubset NCIT_C157711 @default.
- NCIT_C658 inSubset NCIT_C157712 @default.
- NCIT_C658 inSubset NCIT_C176424 @default.
- NCIT_C658 inSubset NCIT_C177537 @default.
- NCIT_C658 inSubset NCIT_C63923 @default.
- NCIT_C658 type Class @default.
- NCIT_C658 isDefinedBy ncit.owl @default.
- NCIT_C658 label "Plicamycin" @default.
- NCIT_C658 subClassOf NCIT_C186664 @default.
- NCIT_C658 subClassOf NCIT_C1908 @default.
- NCIT_C658 subClassOf NCIT_C1909 @default.
- NCIT_C658 subClassOf NCIT_C2115 @default.
- NCIT_C658 subClassOf NCIT_C2161 @default.
- NCIT_C658 subClassOf NCIT_C274 @default.
- NCIT_C658 subClassOf NCIT_C2842 @default.
- NCIT_C658 subClassOf NCIT_C658 @default.
- NCIT_C658 subClassOf NCIT_C67439 @default.
- NCIT_C658 subClassOf NCIT_C78281 @default.