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- NCIT_C65804 IAO_0000115 "An orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities. Gimatecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Although the mechanism of its antiangiogenic activity has yet to be full elucidated, this agent may inhibit endothelial cell migration, tumor neovascularization, and the expression of proangiogenic basic fibroblast growth factor (bFGF)." @default.
- NCIT_C65804 NCIT_A32 NCIT_C1909 @default.
- NCIT_C65804 NCIT_A7 NCIT_C16516 @default.
- NCIT_C65804 NCIT_NHC0 "C65804" @default.
- NCIT_C65804 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65804 NCIT_P107 "Gimatecan" @default.
- NCIT_C65804 NCIT_P108 "Gimatecan" @default.
- NCIT_C65804 NCIT_P207 "C0969276" @default.
- NCIT_C65804 NCIT_P210 "292618-32-7" @default.
- NCIT_C65804 NCIT_P319 "7KKS9R192F" @default.
- NCIT_C65804 NCIT_P322 "CTRP" @default.
- NCIT_C65804 NCIT_P322 "FDA" @default.
- NCIT_C65804 NCIT_P322 "GDC" @default.
- NCIT_C65804 NCIT_P325 "A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called topoisomerase inhibitors." @default.
- NCIT_C65804 NCIT_P329 "537638" @default.
- NCIT_C65804 NCIT_P330 "537638" @default.
- NCIT_C65804 NCIT_P350 "C25H25N3O5" @default.
- NCIT_C65804 NCIT_P366 "Gimatecan" @default.
- NCIT_C65804 NCIT_P375 "Gimatecan" @default.
- NCIT_C65804 NCIT_P399 "537638" @default.
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- NCIT_C65804 NCIT_R146 NCIT_C20646 @default.
- NCIT_C65804 NCIT_R146 NCIT_C26548 @default.
- NCIT_C65804 normalizedInformationContent "100" @default.
- NCIT_C65804 referenceCount "1" @default.
- NCIT_C65804 hasExactSynonym "7-t-Butoxyiminomethylcamptothecin" @default.
- NCIT_C65804 hasExactSynonym "GIMATECAN" @default.
- NCIT_C65804 hasExactSynonym "Gimatecan" @default.
- NCIT_C65804 hasExactSynonym "LBQ707" @default.
- NCIT_C65804 hasExactSynonym "ST1481" @default.
- NCIT_C65804 hasExactSynonym "STI481" @default.
- NCIT_C65804 hasExactSynonym "gimatecan" @default.
- NCIT_C65804 inSubset NCIT_C116977 @default.
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- NCIT_C65804 inSubset NCIT_C128784 @default.
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- NCIT_C65804 type Class @default.
- NCIT_C65804 isDefinedBy ncit.owl @default.
- NCIT_C65804 label "Gimatecan" @default.
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