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- NCIT_C65874 IAO_0000115 "A third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Ibandronic acid binds to and adsorbs onto the surface of hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in the mevalonate pathway. Inhibition of this enzyme prevents the formation of isoprenoids, thereby leading to a reduction in the farnesylation and geranylgeranylation of signaling proteins of G protein-coupled signaling, and, eventually, inducing apoptosis of osteoclasts. By inhibiting osteoclast-mediated bone resorption, ibandronic acid increases bone mineral density, decreases bone remodeling and turnover, as well as reduces bone pain." @default.
- NCIT_C65874 NCIT_NHC0 "C65874" @default.
- NCIT_C65874 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C65874 NCIT_P108 "Ibandronic Acid" @default.
- NCIT_C65874 NCIT_P175 "722623" @default.
- NCIT_C65874 NCIT_P207 "C0379200" @default.
- NCIT_C65874 NCIT_P210 "114084-78-5" @default.
- NCIT_C65874 NCIT_P319 "UMD7G2653W" @default.
- NCIT_C65874 NCIT_P322 "FDA" @default.
- NCIT_C65874 NCIT_P350 "C9H23NO7P2" @default.
- NCIT_C65874 NCIT_P366 "Ibandronic_Acid" @default.
- NCIT_C65874 normalizedInformationContent "100" @default.
- NCIT_C65874 referenceCount "1" @default.
- NCIT_C65874 hasExactSynonym "Bondenza" @default.
- NCIT_C65874 hasExactSynonym "IBANDRONIC ACID" @default.
- NCIT_C65874 hasExactSynonym "Iasibon" @default.
- NCIT_C65874 hasExactSynonym "Ibandronate" @default.
- NCIT_C65874 hasExactSynonym "Ibandronic Acid" @default.
- NCIT_C65874 inSubset NCIT_C63923 @default.
- NCIT_C65874 type Class @default.
- NCIT_C65874 isDefinedBy ncit.owl @default.
- NCIT_C65874 label "Ibandronic Acid" @default.
- NCIT_C65874 subClassOf NCIT_C1908 @default.
- NCIT_C65874 subClassOf NCIT_C1909 @default.
- NCIT_C65874 subClassOf NCIT_C1913 @default.
- NCIT_C65874 subClassOf NCIT_C443 @default.
- NCIT_C65874 subClassOf NCIT_C65874 @default.
- NCIT_C65874 subClassOf NCIT_C67439 @default.
- NCIT_C65874 subClassOf NCIT_C718 @default.
- NCIT_C65874 subClassOf NCIT_C78281 @default.