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- NCIT_C66152 IAO_0000115 "A nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Milfasartan selectively competes with angiotensin II for the binding of the angiotensin II (AT1) receptor subtype 1 in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex. This blocks the effects of aldosterone leading to an increase in sodium excretion and water and eventually a reduction in plasma volume and blood pressure." @default.
- NCIT_C66152 NCIT_NHC0 "C66152" @default.
- NCIT_C66152 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66152 NCIT_P108 "Milfasartan" @default.
- NCIT_C66152 NCIT_P207 "C1881829" @default.
- NCIT_C66152 NCIT_P210 "148564-47-0" @default.
- NCIT_C66152 NCIT_P319 "8UAL5421CL" @default.
- NCIT_C66152 NCIT_P322 "FDA" @default.
- NCIT_C66152 NCIT_P350 "C30H30N6O3S" @default.
- NCIT_C66152 NCIT_P366 "Milfasartan" @default.
- NCIT_C66152 normalizedInformationContent "100" @default.
- NCIT_C66152 referenceCount "1" @default.
- NCIT_C66152 hasExactSynonym "MILFASARTAN" @default.
- NCIT_C66152 hasExactSynonym "Milfasartan" @default.
- NCIT_C66152 inSubset NCIT_C63923 @default.
- NCIT_C66152 type Class @default.
- NCIT_C66152 isDefinedBy ncit.owl @default.
- NCIT_C66152 label "Milfasartan" @default.
- NCIT_C66152 subClassOf NCIT_C1908 @default.
- NCIT_C66152 subClassOf NCIT_C1909 @default.
- NCIT_C66152 subClassOf NCIT_C270 @default.
- NCIT_C66152 subClassOf NCIT_C66152 @default.
- NCIT_C66152 subClassOf NCIT_C66930 @default.
- NCIT_C66152 subClassOf NCIT_C78274 @default.