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- NCIT_C66230 IAO_0000115 "A third-generation, aminohexane bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Although the exact mechanism of action has yet to be fully elucidated, neridronic acid binds to and adsorbs onto hydroxyapatite crystals in bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoids that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, thereby leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, neridronic acid decreases bone turnover rate, stabilizes the bone matrix and reduces hypercalcemia." @default.
- NCIT_C66230 NCIT_NHC0 "C66230" @default.
- NCIT_C66230 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66230 NCIT_P108 "Neridronic Acid" @default.
- NCIT_C66230 NCIT_P207 "C1882065" @default.
- NCIT_C66230 NCIT_P210 "79778-41-9" @default.
- NCIT_C66230 NCIT_P319 "8U27U3RIN4" @default.
- NCIT_C66230 NCIT_P322 "FDA" @default.
- NCIT_C66230 NCIT_P350 "C6H17NO7P2" @default.
- NCIT_C66230 NCIT_P366 "Neridronic_Acid" @default.
- NCIT_C66230 normalizedInformationContent "100" @default.
- NCIT_C66230 referenceCount "1" @default.
- NCIT_C66230 hasExactSynonym "(6-Amino-1-hydroxyhexylidene)diphosphonic Acid" @default.
- NCIT_C66230 hasExactSynonym "NERIDRONIC ACID" @default.
- NCIT_C66230 hasExactSynonym "Neridronic Acid" @default.
- NCIT_C66230 inSubset NCIT_C63923 @default.
- NCIT_C66230 type Class @default.
- NCIT_C66230 isDefinedBy ncit.owl @default.
- NCIT_C66230 label "Neridronic Acid" @default.
- NCIT_C66230 subClassOf NCIT_C1908 @default.
- NCIT_C66230 subClassOf NCIT_C1909 @default.
- NCIT_C66230 subClassOf NCIT_C1913 @default.
- NCIT_C66230 subClassOf NCIT_C443 @default.
- NCIT_C66230 subClassOf NCIT_C66230 @default.
- NCIT_C66230 subClassOf NCIT_C67439 @default.
- NCIT_C66230 subClassOf NCIT_C718 @default.
- NCIT_C66230 subClassOf NCIT_C78281 @default.