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- NCIT_C66237 IAO_0000115 "The sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death." @default.
- NCIT_C66237 NCIT_A6 NCIT_C66236 @default.
- NCIT_C66237 NCIT_NHC0 "C66237" @default.
- NCIT_C66237 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66237 NCIT_P108 "Netilmicin Sulfate" @default.
- NCIT_C66237 NCIT_P207 "C0700550" @default.
- NCIT_C66237 NCIT_P210 "56391-57-2" @default.
- NCIT_C66237 NCIT_P319 "S741ZJS97U" @default.
- NCIT_C66237 NCIT_P322 "FDA" @default.
- NCIT_C66237 NCIT_P350 "2C21H41N5O7.5H2O4S" @default.
- NCIT_C66237 NCIT_P366 "Netilmicin_Sulfate" @default.
- NCIT_C66237 NCIT_P368 "CHEBI:7529" @default.
- NCIT_C66237 normalizedInformationContent "100" @default.
- NCIT_C66237 referenceCount "1" @default.
- NCIT_C66237 hasExactSynonym "NETILMICIN SULFATE" @default.
- NCIT_C66237 hasExactSynonym "Netilmicin Sulfate" @default.
- NCIT_C66237 inSubset NCIT_C63923 @default.
- NCIT_C66237 type Class @default.
- NCIT_C66237 isDefinedBy ncit.owl @default.
- NCIT_C66237 label "Netilmicin Sulfate" @default.
- NCIT_C66237 subClassOf NCIT_C1908 @default.
- NCIT_C66237 subClassOf NCIT_C1909 @default.
- NCIT_C66237 subClassOf NCIT_C2363 @default.
- NCIT_C66237 subClassOf NCIT_C254 @default.
- NCIT_C66237 subClassOf NCIT_C258 @default.
- NCIT_C66237 subClassOf NCIT_C66237 @default.
- NCIT_C66237 subClassOf NCIT_C784 @default.