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- NCIT_C66240 IAO_0000115 "An orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies." @default.
- NCIT_C66240 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66240 NCIT_NHC0 "C66240" @default.
- NCIT_C66240 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66240 NCIT_P107 "Niclosamide" @default.
- NCIT_C66240 NCIT_P108 "Niclosamide" @default.
- NCIT_C66240 NCIT_P207 "C0699963" @default.
- NCIT_C66240 NCIT_P210 "50-65-7" @default.
- NCIT_C66240 NCIT_P319 "8KK8CQ2K8G" @default.
- NCIT_C66240 NCIT_P322 "CTRP" @default.
- NCIT_C66240 NCIT_P322 "FDA" @default.
- NCIT_C66240 NCIT_P322 "GDC" @default.
- NCIT_C66240 NCIT_P329 "775866" @default.
- NCIT_C66240 NCIT_P330 "775866" @default.
- NCIT_C66240 NCIT_P350 "C13H8Cl2N2O4" @default.
- NCIT_C66240 NCIT_P366 "Niclosamide" @default.
- NCIT_C66240 NCIT_P375 "Niclosamide" @default.
- NCIT_C66240 NCIT_P399 "775866" @default.
- NCIT_C66240 normalizedInformationContent "100" @default.
- NCIT_C66240 referenceCount "1" @default.
- NCIT_C66240 hasExactSynonym "Benzamide, 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-" @default.
- NCIT_C66240 hasExactSynonym "NICLOSAMIDE" @default.
- NCIT_C66240 hasExactSynonym "Niclosamide" @default.
- NCIT_C66240 hasExactSynonym "Salicylanilide, 2',5-Dichloro-4'-nitro-" @default.
- NCIT_C66240 inSubset NCIT_C116977 @default.
- NCIT_C66240 inSubset NCIT_C116978 @default.
- NCIT_C66240 inSubset NCIT_C128784 @default.
- NCIT_C66240 inSubset NCIT_C157711 @default.
- NCIT_C66240 inSubset NCIT_C157712 @default.
- NCIT_C66240 inSubset NCIT_C173381 @default.
- NCIT_C66240 inSubset NCIT_C173383 @default.
- NCIT_C66240 inSubset NCIT_C176424 @default.
- NCIT_C66240 inSubset NCIT_C177537 @default.
- NCIT_C66240 inSubset NCIT_C63923 @default.
- NCIT_C66240 type Class @default.
- NCIT_C66240 isDefinedBy ncit.owl @default.
- NCIT_C66240 label "Niclosamide" @default.
- NCIT_C66240 subClassOf NCIT_C1908 @default.
- NCIT_C66240 subClassOf NCIT_C1909 @default.
- NCIT_C66240 subClassOf NCIT_C250 @default.
- NCIT_C66240 subClassOf NCIT_C254 @default.
- NCIT_C66240 subClassOf NCIT_C276 @default.
- NCIT_C66240 subClassOf NCIT_C66240 @default.