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- NCIT_C66318 IAO_0000115 "An amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation." @default.
- NCIT_C66318 NCIT_NHC0 "C66318" @default.
- NCIT_C66318 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66318 NCIT_P108 "Parecoxib" @default.
- NCIT_C66318 NCIT_P207 "C0915142" @default.
- NCIT_C66318 NCIT_P210 "198470-84-7" @default.
- NCIT_C66318 NCIT_P319 "9TUW81Y3CE" @default.
- NCIT_C66318 NCIT_P322 "FDA" @default.
- NCIT_C66318 NCIT_P350 "C19H18N2O4S" @default.
- NCIT_C66318 NCIT_P366 "Parecoxib" @default.
- NCIT_C66318 normalizedInformationContent "100" @default.
- NCIT_C66318 referenceCount "1" @default.
- NCIT_C66318 hasExactSynonym "PARECOXIB" @default.
- NCIT_C66318 hasExactSynonym "Parecoxib" @default.
- NCIT_C66318 hasExactSynonym "Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)-" @default.
- NCIT_C66318 inSubset NCIT_C63923 @default.
- NCIT_C66318 type Class @default.
- NCIT_C66318 isDefinedBy ncit.owl @default.
- NCIT_C66318 label "Parecoxib" @default.
- NCIT_C66318 subClassOf NCIT_C1323 @default.
- NCIT_C66318 subClassOf NCIT_C1908 @default.
- NCIT_C66318 subClassOf NCIT_C1909 @default.
- NCIT_C66318 subClassOf NCIT_C2198 @default.
- NCIT_C66318 subClassOf NCIT_C2356 @default.
- NCIT_C66318 subClassOf NCIT_C241 @default.
- NCIT_C66318 subClassOf NCIT_C257 @default.
- NCIT_C66318 subClassOf NCIT_C471 @default.
- NCIT_C66318 subClassOf NCIT_C66318 @default.
- NCIT_C66318 subClassOf NCIT_C78272 @default.