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- NCIT_C66323 IAO_0000115 "The hydrochloride salt form of pargyline, a monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect." @default.
- NCIT_C66323 NCIT_A6 NCIT_C66322 @default.
- NCIT_C66323 NCIT_NHC0 "C66323" @default.
- NCIT_C66323 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66323 NCIT_P108 "Pargyline Hydrochloride" @default.
- NCIT_C66323 NCIT_P175 "43798" @default.
- NCIT_C66323 NCIT_P207 "C0282289" @default.
- NCIT_C66323 NCIT_P210 "306-07-0" @default.
- NCIT_C66323 NCIT_P319 "W70V6I2OMY" @default.
- NCIT_C66323 NCIT_P322 "FDA" @default.
- NCIT_C66323 NCIT_P350 "C11H13N.HCl" @default.
- NCIT_C66323 NCIT_P366 "Pargyline_Hydrochloride" @default.
- NCIT_C66323 normalizedInformationContent "100" @default.
- NCIT_C66323 referenceCount "1" @default.
- NCIT_C66323 hasExactSynonym "PARGYLINE HYDROCHLORIDE" @default.
- NCIT_C66323 hasExactSynonym "Pargyline Hydrochloride" @default.
- NCIT_C66323 inSubset NCIT_C63923 @default.
- NCIT_C66323 type Class @default.
- NCIT_C66323 isDefinedBy ncit.owl @default.
- NCIT_C66323 label "Pargyline Hydrochloride" @default.
- NCIT_C66323 subClassOf NCIT_C1908 @default.
- NCIT_C66323 subClassOf NCIT_C1909 @default.
- NCIT_C66323 subClassOf NCIT_C270 @default.
- NCIT_C66323 subClassOf NCIT_C471 @default.
- NCIT_C66323 subClassOf NCIT_C66323 @default.
- NCIT_C66323 subClassOf NCIT_C667 @default.
- NCIT_C66323 subClassOf NCIT_C78274 @default.