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- NCIT_C66337 IAO_0000115 "A synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited." @default.
- NCIT_C66337 NCIT_A5 NCIT_C47656 @default.
- NCIT_C66337 NCIT_NHC0 "C66337" @default.
- NCIT_C66337 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66337 NCIT_P108 "Penciclovir" @default.
- NCIT_C66337 NCIT_P207 "C0164815" @default.
- NCIT_C66337 NCIT_P210 "39809-25-1" @default.
- NCIT_C66337 NCIT_P319 "359HUE8FJC" @default.
- NCIT_C66337 NCIT_P322 "FDA" @default.
- NCIT_C66337 NCIT_P350 "C10H15N5O3" @default.
- NCIT_C66337 NCIT_P366 "Penciclovir" @default.
- NCIT_C66337 NCIT_P368 "CHEBI:7956" @default.
- NCIT_C66337 normalizedInformationContent "100" @default.
- NCIT_C66337 referenceCount "1" @default.
- NCIT_C66337 hasExactSynonym "6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-" @default.
- NCIT_C66337 hasExactSynonym "9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine" @default.
- NCIT_C66337 hasExactSynonym "BRL 39123" @default.
- NCIT_C66337 hasExactSynonym "BRL-39123" @default.
- NCIT_C66337 hasExactSynonym "CCRIS 9213" @default.
- NCIT_C66337 hasExactSynonym "Denavir" @default.
- NCIT_C66337 hasExactSynonym "PENCICLOVIR" @default.
- NCIT_C66337 hasExactSynonym "Penciclovir" @default.
- NCIT_C66337 inSubset NCIT_C63923 @default.
- NCIT_C66337 type Class @default.
- NCIT_C66337 isDefinedBy ncit.owl @default.
- NCIT_C66337 label "Penciclovir" @default.
- NCIT_C66337 subClassOf NCIT_C1908 @default.
- NCIT_C66337 subClassOf NCIT_C1909 @default.
- NCIT_C66337 subClassOf NCIT_C254 @default.
- NCIT_C66337 subClassOf NCIT_C281 @default.
- NCIT_C66337 subClassOf NCIT_C29575 @default.
- NCIT_C66337 subClassOf NCIT_C471 @default.
- NCIT_C66337 subClassOf NCIT_C66337 @default.