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- NCIT_C66420 IAO_0000115 "A synthetic pyridinyl bisphosphonate with anti-resorptive activity. Although the exact mechanism of action has yet to be fully elucidated, piridronic acid likely binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, piridronic acid decreases bone turnover and stabilizes the bone matrix." @default.
- NCIT_C66420 NCIT_NHC0 "C66420" @default.
- NCIT_C66420 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66420 NCIT_P108 "Piridronic Acid" @default.
- NCIT_C66420 NCIT_P207 "C0045686" @default.
- NCIT_C66420 NCIT_P210 "75755-07-6" @default.
- NCIT_C66420 NCIT_P319 "ADD4H8T3K9" @default.
- NCIT_C66420 NCIT_P322 "FDA" @default.
- NCIT_C66420 NCIT_P350 "C7H11NO6P2" @default.
- NCIT_C66420 NCIT_P366 "Piridronic_Acid" @default.
- NCIT_C66420 normalizedInformationContent "100" @default.
- NCIT_C66420 referenceCount "1" @default.
- NCIT_C66420 hasExactSynonym "2-(2-Pyridyl)ethylidine-1,1-bisphosphonate" @default.
- NCIT_C66420 hasExactSynonym "PIRIDRONIC ACID" @default.
- NCIT_C66420 hasExactSynonym "Piridronic Acid" @default.
- NCIT_C66420 inSubset NCIT_C63923 @default.
- NCIT_C66420 type Class @default.
- NCIT_C66420 isDefinedBy ncit.owl @default.
- NCIT_C66420 label "Piridronic Acid" @default.
- NCIT_C66420 subClassOf NCIT_C1908 @default.
- NCIT_C66420 subClassOf NCIT_C1909 @default.
- NCIT_C66420 subClassOf NCIT_C1913 @default.
- NCIT_C66420 subClassOf NCIT_C2136 @default.
- NCIT_C66420 subClassOf NCIT_C443 @default.
- NCIT_C66420 subClassOf NCIT_C66420 @default.
- NCIT_C66420 subClassOf NCIT_C67439 @default.
- NCIT_C66420 subClassOf NCIT_C718 @default.
- NCIT_C66420 subClassOf NCIT_C78275 @default.
- NCIT_C66420 subClassOf NCIT_C78281 @default.