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- NCIT_C66443 IAO_0000115 "An angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, the free SH metabolite of pivopril competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Pivopril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C66443 NCIT_NHC0 "C66443" @default.
- NCIT_C66443 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66443 NCIT_P108 "Pivopril" @default.
- NCIT_C66443 NCIT_P207 "C1882404" @default.
- NCIT_C66443 NCIT_P210 "81045-50-3" @default.
- NCIT_C66443 NCIT_P319 "3V6I5962EM" @default.
- NCIT_C66443 NCIT_P322 "FDA" @default.
- NCIT_C66443 NCIT_P350 "C16H27NO4S" @default.
- NCIT_C66443 NCIT_P366 "Pivopril" @default.
- NCIT_C66443 normalizedInformationContent "100" @default.
- NCIT_C66443 referenceCount "1" @default.
- NCIT_C66443 hasExactSynonym "PIVOPRIL" @default.
- NCIT_C66443 hasExactSynonym "Pivopril" @default.
- NCIT_C66443 inSubset NCIT_C63923 @default.
- NCIT_C66443 type Class @default.
- NCIT_C66443 isDefinedBy ncit.owl @default.
- NCIT_C66443 label "Pivopril" @default.
- NCIT_C66443 subClassOf NCIT_C1908 @default.
- NCIT_C66443 subClassOf NCIT_C1909 @default.
- NCIT_C66443 subClassOf NCIT_C247 @default.
- NCIT_C66443 subClassOf NCIT_C270 @default.
- NCIT_C66443 subClassOf NCIT_C471 @default.
- NCIT_C66443 subClassOf NCIT_C66443 @default.
- NCIT_C66443 subClassOf NCIT_C78274 @default.
- NCIT_C66443 subClassOf NCIT_C783 @default.