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- NCIT_C66496 IAO_0000115 "The hydrochloride salt form of protokylol, a derivative of the beta-adrenergic receptor agonist isoproterenol with bronchodilator activity. Protokylol binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells." @default.
- NCIT_C66496 NCIT_A6 NCIT_C74198 @default.
- NCIT_C66496 NCIT_NHC0 "C66496" @default.
- NCIT_C66496 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66496 NCIT_P108 "Protokylol Hydrochloride" @default.
- NCIT_C66496 NCIT_P207 "C0770472" @default.
- NCIT_C66496 NCIT_P210 "136-69-6" @default.
- NCIT_C66496 NCIT_P319 "7U7O8Q48IO" @default.
- NCIT_C66496 NCIT_P322 "FDA" @default.
- NCIT_C66496 NCIT_P350 "C18H21NO5.HCl" @default.
- NCIT_C66496 NCIT_P366 "Protokylol_Hydrochloride" @default.
- NCIT_C66496 normalizedInformationContent "100" @default.
- NCIT_C66496 referenceCount "1" @default.
- NCIT_C66496 hasExactSynonym "PROTOKYLOL HYDROCHLORIDE" @default.
- NCIT_C66496 hasExactSynonym "Protokylol Hydrochloride" @default.
- NCIT_C66496 inSubset NCIT_C63923 @default.
- NCIT_C66496 type Class @default.
- NCIT_C66496 isDefinedBy ncit.owl @default.
- NCIT_C66496 label "Protokylol Hydrochloride" @default.
- NCIT_C66496 subClassOf NCIT_C1908 @default.
- NCIT_C66496 subClassOf NCIT_C1909 @default.
- NCIT_C66496 subClassOf NCIT_C29747 @default.
- NCIT_C66496 subClassOf NCIT_C48149 @default.
- NCIT_C66496 subClassOf NCIT_C66496 @default.
- NCIT_C66496 subClassOf NCIT_C78272 @default.
- NCIT_C66496 subClassOf NCIT_C87053 @default.